AKTIP and RASGRF2

Data Source:
BioGRID (two hybrid)

		AKTIP	RASGRF2
Description		AKT interacting protein	Ras protein specific guanine nucleotide releasing factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane HOPS Complex FHF Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity	Guanyl-nucleotide Exchange Factor Activity Calmodulin Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Apoptotic Process Cellular Response To DNA Damage Stimulus Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Protein Phosphopantetheinylation Positive Regulation Of Protein Binding Early Endosome To Late Endosome Transport	MAPK Cascade G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Response To Endoplasmic Reticulum Stress Regulation Of Rho Protein Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Long-term Synaptic Potentiation Regulation Of NMDA Receptor Activity
Pathways			NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depressive symptoms (SSRI exposure interaction) ( 25649181) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip circumference adjusted for BMI ( 25673412) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Adventurousness ( 30643258) Eating disorders ( 23568457) Eating disorders (purging via substances) ( 23568457) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549 28869591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mucinous adenocarcinoma in colorectal cancer ( 29942513) Orofacial clefts ( 22419666) Response to ketamine in bipolar disorder or major depression (dissociation effects) ( 30552317) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Statin-induced myopathy (severe) ( 31220337) Superior frontal gyrus grey matter volume ( 25335168)
Interacting Genes		34 interacting genes: ACTN2 AKT1 ASS1 CEP126 CTBP2 DMXL2 DZIP3 EXOC7 FHIP1B GTF3C1 HOOK1 HOOK2 HOOK3 IMMT IPO7 LMNA MAP3K7 MARCHF5 MATR3 NEB PDE4DIP PDPK1 POLA2 RASGRF2 RPA1 TRIM23 TRIM32 TRIM41 TWNK UPF2 UTP14A VPS16 VPS18 VPS41	5 interacting genes: AKTIP CDC42 KRAS RAC1 RHOA
Entrez ID		64400	5924
HPRD ID		07467	07588
Ensembl ID		ENSG00000166971	ENSG00000113319
Uniprot IDs		A0A024R6S6 A0A024R6T5 Q9H8T0	A0A2X0SFL3 O14827 Q68DX5
PDB IDs
Enriched GO Terms of Interacting Partners?
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