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SFRP2 and BUB1
Data Source:
BioGRID
(two hybrid)
SFRP2
BUB1
Description
secreted frizzled related protein 2
BUB1 mitotic checkpoint serine/threonine kinase
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Collagen-containing Extracellular Matrix
Kinetochore
Condensed Chromosome Kinetochore
Condensed Nuclear Chromosome Kinetochore
Condensed Nuclear Chromosome Outer Kinetochore
Nucleoplasm
Cytosol
Membrane
Intracellular Membrane-bounded Organelle
Molecular Function
Fibronectin Binding
Integrin Binding
Wnt-protein Binding
Receptor Ligand Activity
Endopeptidase Activator Activity
Protein Kinase Activity
Protein Binding
ATP Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Branching Involved In Blood Vessel Morphogenesis
Chondrocyte Development
Outflow Tract Morphogenesis
Cardiac Left Ventricle Morphogenesis
Apoptotic Process
Cell-cell Signaling
Response To Nutrient
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Male Gonad Development
Negative Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Negative Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Endopeptidase Activity
Regulation Of Neuron Projection Development
Negative Regulation Of Wnt Signaling Pathway
Collagen Fibril Organization
Positive Regulation Of Cell Growth
Negative Regulation Of Cell Growth
Negative Regulation Of Cell Migration
Negative Regulation Of BMP Signaling Pathway
Cellular Response To Extracellular Stimulus
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Cell Adhesion Mediated By Integrin
Non-canonical Wnt Signaling Pathway
Post-anal Tail Morphogenesis
Response To Drug
Negative Regulation Of Mesodermal Cell Fate Specification
Embryonic Digit Morphogenesis
Positive Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of JUN Kinase Activity
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Angiogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Morphogenesis
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
Convergent Extension Involved In Axis Elongation
Canonical Wnt Signaling Pathway
Bone Morphogenesis
Sclerotome Development
Negative Regulation Of Dermatome Development
Hematopoietic Stem Cell Proliferation
Cellular Response To X-ray
Negative Regulation Of Canonical Wnt Signaling Pathway
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Wnt Signaling Pathway Involved In Somitogenesis
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Midbrain Dopaminergic Neuron Differentiation
Regulation Of Stem Cell Division
Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation
Protein Phosphorylation
Apoptotic Process
Regulation Of Sister Chromatid Cohesion
Mitotic Cell Cycle Checkpoint
Mitotic Spindle Assembly Checkpoint
Cell Population Proliferation
Viral Process
Cell Division
Meiotic Sister Chromatid Cohesion, Centromeric
Regulation Of Chromosome Segregation
Pathways
TCF dependent signaling in response to WNT
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS
Bone mineral density (spine) (
30172743
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Facial morphology (
31763980
)
Macular thickness (
30535121
)
Nose morphology (
29921221
)
Subcortical volume (MOSTest) (
32665545
)
Type 2 diabetes (age of onset) (
28060188
)
Interacting Genes
15 interacting genes:
BMPR1A
BUB1
CDH1
CTNNA1
DBNDD2
DCC
EEF1G
MLH3
PAX2
PFKM
RAD54B
SFRP5
SMAD4
WNT1
WNT4
63 interacting genes:
AKT1
ALDOB
ANP32B
AOPEP
AP1B1
AP2B1
AP3B1
AP4B1
APC
ARIH2
BAAT
BUB3
CCDC180
CDC14B
CDC20
CDK1
CDK8
CORO2A
CRK
CTSV
CYLC2
DVL1
EIF4EBP1
FANCC
FBP1
FBP2
FBXO7
FRAT2
GALNT12
HDAC1
HEMGN
HRAS
HSD17B3
IGFBP3
KNL1
LEF1
MAP2K1
MAPK3
MSANTD3
NANS
PLK1
PPP2CB
PPP3R2
RAE1
RASA1
RDH12
SEC61B
SFRP2
SFRP4
SHC1
SMAD1
STX17
SVIL
TBC1D2
TDRD7
TGFB1
TMEFF1
TMOD1
TRMO
TSTD2
XPA
ZNF189
ZNF510
Entrez ID
6423
699
HPRD ID
16041
03907
Ensembl ID
ENSG00000145423
ENSG00000169679
Uniprot IDs
A0A140VJU3
B3KSM5
Q96HF1
B4DYG2
O43683
PDB IDs
2LAH
4A1G
4QPM
4R8Q
5DMZ
6F7B
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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