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SFRP2 and MLH3
Data Source:
BioGRID
(two hybrid)
SFRP2
MLH3
Description
secreted frizzled related protein 2
mutL homolog 3
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Collagen-containing Extracellular Matrix
Synaptonemal Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chiasma
Mismatch Repair Complex
Molecular Function
Fibronectin Binding
Integrin Binding
Wnt-protein Binding
Receptor Ligand Activity
Endopeptidase Activator Activity
Chromatin Binding
Satellite DNA Binding
Protein Binding
ATP Binding
ATPase Activity
Centromeric DNA Binding
Mismatched DNA Binding
Biological Process
Branching Involved In Blood Vessel Morphogenesis
Chondrocyte Development
Outflow Tract Morphogenesis
Cardiac Left Ventricle Morphogenesis
Apoptotic Process
Cell-cell Signaling
Response To Nutrient
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Male Gonad Development
Negative Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Negative Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Endopeptidase Activity
Regulation Of Neuron Projection Development
Negative Regulation Of Wnt Signaling Pathway
Collagen Fibril Organization
Positive Regulation Of Cell Growth
Negative Regulation Of Cell Growth
Negative Regulation Of Cell Migration
Negative Regulation Of BMP Signaling Pathway
Cellular Response To Extracellular Stimulus
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Cell Adhesion Mediated By Integrin
Non-canonical Wnt Signaling Pathway
Post-anal Tail Morphogenesis
Response To Drug
Negative Regulation Of Mesodermal Cell Fate Specification
Embryonic Digit Morphogenesis
Positive Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of JUN Kinase Activity
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Angiogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Morphogenesis
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
Convergent Extension Involved In Axis Elongation
Canonical Wnt Signaling Pathway
Bone Morphogenesis
Sclerotome Development
Negative Regulation Of Dermatome Development
Hematopoietic Stem Cell Proliferation
Cellular Response To X-ray
Negative Regulation Of Canonical Wnt Signaling Pathway
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Wnt Signaling Pathway Involved In Somitogenesis
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Midbrain Dopaminergic Neuron Differentiation
Regulation Of Stem Cell Division
Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation
Mismatch Repair
Synaptonemal Complex Assembly
Reciprocal Meiotic Recombination
Male Meiotic Nuclear Division
Female Meiosis I
Protein Localization
Pathways
TCF dependent signaling in response to WNT
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Meiotic recombination
Drugs
Diseases
Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS
Bone mineral density (spine) (
30172743
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Facial morphology (
31763980
)
Macular thickness (
30535121
)
Nose morphology (
29921221
)
Subcortical volume (MOSTest) (
32665545
)
Type 2 diabetes (age of onset) (
28060188
)
Inflammatory bowel disease (
23128233
)
Mood instability (
29187730
)
Refractive error (
32231278
)
Interacting Genes
15 interacting genes:
BMPR1A
BUB1
CDH1
CTNNA1
DBNDD2
DCC
EEF1G
MLH3
PAX2
PFKM
RAD54B
SFRP5
SMAD4
WNT1
WNT4
45 interacting genes:
AKT1
ALDOB
ANP32B
AOPEP
AR
BAAT
CCDC180
CDC14B
CDK8
CTSV
CYLC2
DVL1
FANCC
FBP1
FBP2
FRAT2
GALNT12
HEMGN
HRAS
HSD17B3
IGFBP3
LEF1
MAP2K1
MLH1
MSANTD3
MSH4
NANS
PPP2CB
PPP3R2
RASA1
SEC61B
SFRP2
SMAD1
STX17
TBC1D2
TDRD7
TGFB1
TMEFF1
TMOD1
TRIM55
TRIM63
TSTD2
XPA
ZDHHC17
ZNF510
Entrez ID
6423
27030
HPRD ID
16041
05094
Ensembl ID
ENSG00000145423
ENSG00000119684
Uniprot IDs
A0A140VJU3
B3KSM5
Q96HF1
Q2M1Z1
Q9UHC1
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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