BUB1 and HSD17B3

Data Source:
BioGRID (two hybrid)

		BUB1	HSD17B3
Description		BUB1 mitotic checkpoint serine/threonine kinase	hydroxysteroid 17-beta dehydrogenase 3
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Nucleoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Estradiol 17-beta-dehydrogenase Activity Testosterone 17-beta-dehydrogenase (NADP+) Activity
	Biological Process	Protein Phosphorylation Apoptotic Process Regulation Of Sister Chromatid Cohesion Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Cell Population Proliferation Viral Process Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Chromosome Segregation	Steroid Biosynthetic Process Androgen Biosynthetic Process Male Genitalia Development Testosterone Biosynthetic Process
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Androgen biosynthesis Synthesis of very long-chain fatty acyl-CoAs
Drugs			NADH
Diseases			46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS			Cerebrospinal fluid AB1-42 levels ( 26252872) Glomerular filtration rate in chronic kidney disease ( 26420894) Letter-number span reordering ( 31596458)
Interacting Genes		63 interacting genes: AKT1 ALDOB ANP32B AOPEP AP1B1 AP2B1 AP3B1 AP4B1 APC ARIH2 BAAT BUB3 CCDC180 CDC14B CDC20 CDK1 CDK8 CORO2A CRK CTSV CYLC2 DVL1 EIF4EBP1 FANCC FBP1 FBP2 FBXO7 FRAT2 GALNT12 HDAC1 HEMGN HRAS HSD17B3 IGFBP3 KNL1 LEF1 MAP2K1 MAPK3 MSANTD3 NANS PLK1 PPP2CB PPP3R2 RAE1 RASA1 RDH12 SEC61B SFRP2 SFRP4 SHC1 SMAD1 STX17 SVIL TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRMO TSTD2 XPA ZNF189 ZNF510	9 interacting genes: BRAF BUB1 CDH1 CTNNA1 DLC1 ERBB2 MCC MLH3 SMAD2
Entrez ID		699	3293
HPRD ID		03907	05716
Ensembl ID		ENSG00000169679	ENSG00000130948
Uniprot IDs		B4DYG2 O43683	P37058 Q6FH62
PDB IDs		2LAH 4A1G 4QPM 4R8Q 5DMZ 6F7B
Enriched GO Terms of Interacting Partners?
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