H2BC1 and USP44

Data Source:
BioGRID (enzymatic study)

		H2BC1	USP44
Description		H2B clustered histone 1	ubiquitin specific peptidase 44
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleosome Nucleus Nucleoplasm Extrinsic Component Of Plasma Membrane	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Molecular_function DNA Binding Histone Binding Protein Heterodimerization Activity	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Zinc Ion Binding
	Biological Process	Nucleosome Assembly Nucleosome Disassembly Inflammatory Response Protein Ubiquitination Plasminogen Activation Spermatogenesis, Exchange Of Chromosomal Proteins Positive Regulation Of Binding Mononuclear Cell Migration	Cell Cycle Chromosome Segregation Protein Deubiquitination Protein Phosphopantetheinylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of Ubiquitin Protein Ligase Activity
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation	Ub-specific processing proteases
Drugs
Diseases
GWAS			Brain volume in infants (white matter) ( 28763065) Breast size ( 27182965) C-reactive protein levels ( 30388399) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Response to anti-depressant treatment in major depressive disorder ( 22041458) Type 2 diabetes ( 30297969)
Interacting Genes		8 interacting genes: ANP32B APP CCNA1 DNTTIP2 H2AC20 HDAC3 SET USP44	1 interacting genes: H2BC1
Entrez ID		255626	84101
HPRD ID		11024	15636
Ensembl ID		ENSG00000146047	ENSG00000136014
Uniprot IDs		Q96A08	A0A024RBD7 Q9H0E7
PDB IDs		3WKJ 5GSU 5GT3 6BIY
Enriched GO Terms of Interacting Partners?
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