PBLD and AMOT

Data Source:
BioGRID (two hybrid)

		PBLD	AMOT
Description		phenazine biosynthesis like protein domain containing	angiomotin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Extracellular Exosome	Ruffle Nucleoplasm Cytosol Actin Filament Plasma Membrane Bicellular Tight Junction COP9 Signalosome External Side Of Plasma Membrane Lamellipodium Cell Junction Endocytic Vesicle Cytoplasmic Vesicle
	Molecular Function	Molecular_function Protein Binding Isomerase Activity Identical Protein Binding	Protein Binding Signaling Receptor Activity Angiostatin Binding
	Biological Process	Biosynthetic Process Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Angiogenesis Vasculogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Chemotaxis Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Regulation Of Cell Migration Negative Regulation Of GTPase Activity Cellular Protein Localization Hippo Signaling Positive Regulation Of Embryonic Development Cell Migration Involved In Gastrulation Blood Vessel Endothelial Cell Migration Regulation Of Small GTPase Mediated Signal Transduction
Pathways
Drugs
Diseases
GWAS		Optic disc parameters ( 20548946) Optic disc radius ( 31597446) Optic disc size ( 31809533) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Optic nerve measurement (disc area) ( 20395239) Vertical cup-disc ratio ( 20548946)
Interacting Genes		11 interacting genes: AMOT BEND7 CCDC184 EFHC2 GRAP2 LNX1 STRAP TCF4 TRIP13 VAC14 ZRANB1	60 interacting genes: ACTA1 AMOTL2 AP1M1 APP AQP1 AXIN2 C1orf216 CAPN3 DISC1 FHL2 HOXA1 HPCAL1 KIAA1328 KRT14 KRT15 KRT16 KRT19 KRT24 KRT27 KRT31 KRT34 KRT36 KRT75 LCE1D LMNB2 LMO4 LURAP1 LZTS1 MAGEA4 MAGI1 MAPK3 MED4 MEOX2 MIS18A MYBPC1 MYBPC2 MYOM3 NEDD4 NEDD4L NF2 NTAQ1 NUFIP2 PBLD PIBF1 PIK3C2A PIN1 PLG PRKAA2 PTEN PTPA PTPN14 RBM48 SEPTIN1 SLIRP SMC1A SNAPC5 SOCS6 THRA TTN UNC119
Entrez ID		64081	154796
HPRD ID		14366	02327
Ensembl ID		ENSG00000108187	ENSG00000126016
Uniprot IDs		A0A024QZK5 P30039	Q4VCS5
PDB IDs			6JJX
Enriched GO Terms of Interacting Partners?
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