AMOT and PIK3C2A

Data Source:
BioGRID (two hybrid)

		AMOT	PIK3C2A
Description		angiomotin	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
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GO Annotations	Cellular Component	Ruffle Nucleoplasm Cytosol Actin Filament Plasma Membrane Bicellular Tight Junction COP9 Signalosome External Side Of Plasma Membrane Lamellipodium Cell Junction Endocytic Vesicle Cytoplasmic Vesicle	Nucleoplasm Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Membrane Clathrin-coated Vesicle Vesicle Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Protein Binding Signaling Receptor Activity Angiostatin Binding	ATP Binding 1-phosphatidylinositol-3-kinase Activity Clathrin Binding Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol Kinase Activity Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity
	Biological Process	Angiogenesis Vasculogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Chemotaxis Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Regulation Of Cell Migration Negative Regulation Of GTPase Activity Cellular Protein Localization Hippo Signaling Positive Regulation Of Embryonic Development Cell Migration Involved In Gastrulation Blood Vessel Endothelial Cell Migration Regulation Of Small GTPase Mediated Signal Transduction	Phosphatidylinositol Biosynthetic Process Exocytosis Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Autophagy Phosphatidylinositol 3-kinase Signaling Vascular Associated Smooth Muscle Contraction Cell Migration Phosphatidylinositol-3-phosphate Biosynthetic Process Phosphatidylinositol Phosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Clathrin Coat Assembly Membrane Organization Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways			Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS			Body mass index ( 26426971) Platelet count ( 32888494) Schizophrenia or bipolar disorder ( 24280982) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		60 interacting genes: ACTA1 AMOTL2 AP1M1 APP AQP1 AXIN2 C1orf216 CAPN3 DISC1 FHL2 HOXA1 HPCAL1 KIAA1328 KRT14 KRT15 KRT16 KRT19 KRT24 KRT27 KRT31 KRT34 KRT36 KRT75 LCE1D LMNB2 LMO4 LURAP1 LZTS1 MAGEA4 MAGI1 MAPK3 MED4 MEOX2 MIS18A MYBPC1 MYBPC2 MYOM3 NEDD4 NEDD4L NF2 NTAQ1 NUFIP2 PBLD PIBF1 PIK3C2A PIN1 PLG PRKAA2 PTEN PTPA PTPN14 RBM48 SEPTIN1 SLIRP SMC1A SNAPC5 SOCS6 THRA TTN UNC119	3 interacting genes: AMOT EGFR ERBB2
Entrez ID		154796	5286
HPRD ID		02327	04672
Ensembl ID		ENSG00000126016	ENSG00000011405
Uniprot IDs		Q4VCS5	B4DG55 L7RRS0 O00443
PDB IDs		6JJX	2AR5 2IWL 2REA 2RED 6BTY 6BTZ 6BU0 6BUB
Enriched GO Terms of Interacting Partners?
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