NPAS3 and TRIM32

Data Source:
BioGRID (genetic interference)

		NPAS3	TRIM32
Description		neuronal PAS domain protein 3	tripartite motif containing 32
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm	Nucleus Cytoplasm Cytosol Striated Muscle Myosin Thick Filament
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Heterodimerization Activity	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Myosin Binding Tat Protein Binding Translation Initiation Factor Binding Identical Protein Binding Ubiquitin Binding Protein Self-association Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription, DNA-templated	Protein Polyubiquitination Tissue Homeostasis Ubiquitin-dependent Protein Catabolic Process Actin Ubiquitination Response To UV Protein Ubiquitination Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Response To Tumor Necrosis Factor Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Positive Regulation Of Transcription, DNA-templated Muscle Cell Cellular Homeostasis Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Striated Muscle Cell Differentiation Axon Development Protein K48-linked Ubiquitination Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Positive Regulation Of Cell Motility
Pathways			Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Alcoholic chronic pancreatitis ( 28754779) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Arterial stiffness index ( 31235810) Bipolar disorder ( 31043756) Body mass index ( 26426971 28892062 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Coffee consumption ( 31046077) Colorectal or endometrial cancer ( 26621817) Diisocyanate-induced asthma ( 25918132) Familial squamous cell lung carcinoma ( 29924316) Height ( 28552196) Inflammatory biomarkers ( 22228203) Intraocular pressure ( 29617998) Lean body mass ( 28552196) Metabolite levels ( 23823483) Mitochondrial DNA levels ( 25240745) Moderate-to-late spontaneous preterm birth ( 31194736) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Night sleep phenotypes ( 27126917) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) QRS duration in Tripanosoma cruzi seropositivity ( 24324551) Schizophrenia ( 28991256) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Serum immune biomarker levels ( 32066700) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Squamous cell lung carcinoma ( 28604730)	Estimated glomerular filtration rate ( 31015462)
Interacting Genes		2 interacting genes: ARNT2 CHRM5	63 interacting genes: ABI2 AKTIP ATXN1 CLIP4 DERL1 ERGIC3 FADS6 GABARAP GABARAPL1 GABARAPL2 GEM GLIS2 GPR137B HSPA4 ICMT IQCB1 IRAK1 KCTD9 LCN2 MAP1LC3A MAP1LC3B MAP1LC3C MID2 MOB1A MYCN NDRG2 NTAQ1 PDE9A PELI2 PIAS3 PIAS4 PTCD2 PTPN11 RAB29 RABAC1 RNF208 RNF41 SCGB1A1 SDCBP STING1 SYT6 TCEANC TOP1 TRIM23 TRIM27 TRIM5 TRIM72 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBE2V1 UBQLN1 UBQLN2 UBQLN4 VPS11 XIAP
Entrez ID		64067	22954
HPRD ID		11400	03797
Ensembl ID		ENSG00000151322	ENSG00000119401
Uniprot IDs		Q8IXF0 X5D2Q4 X5D7M0 X5D988	A0A024R843 Q13049
PDB IDs			2CT2 5FEY
Enriched GO Terms of Interacting Partners?
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