PERP and MAL

Data Source:
BioGRID (two hybrid)

		PERP	MAL
Description		p53 apoptosis effector related to PMP22	mal, T cell differentiation protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Desmosome	Endoplasmic Reticulum Integral Component Of Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Membrane Raft
	Molecular Function	Protein Binding	Protein Binding Lipid Binding Peptidase Activator Activity Involved In Apoptotic Process Structural Constituent Of Myelin Sheath
	Biological Process	Desmosome Organization Notch Signaling Pathway Heterotypic Cell-cell Adhesion Regulation Of Apoptotic Process Positive Regulation Of Proteolysis Cornification Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Amelogenesis Activation Of Cysteine-type Endopeptidase Activity Cell-cell Adhesion	Membrane Raft Polarization Apoptotic Process Central Nervous System Development Cell Differentiation Myelination Apical Protein Localization
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Formation of the cornified envelope
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Bulimia nervosa ( 23568457) Systemic lupus erythematosus ( 26663301)
Interacting Genes		2 interacting genes: ABHD16A MAL	81 interacting genes: AMHR2 AQP6 BCL2L13 BTN2A1 CALN1 CD300LG CD3G CD40 CD53 CD69 CLDN14 CLDN20 CLDN7 CLDN9 CLEC4C CLSTN3 CPLX4 CREB3L1 CXADR DAGLA EDA EMP1 EVI2A FAM209A FCRL2 FIBCD1 FNDC9 GJA8 GJB1 GPR152 GRAMD1A GSG1L HIBADH IL10RA IL20RB JAML KCNA1 KCNA10 KCNMB4 KLRC1 LDLRAD1 LMAN2L LMNA LRRC25 LRTM1 LSMEM1 MC4R MS4A4A MYD88 NCAPH2 NKAIN4 NPDC1 OPRM1 PERP PLA2G10 PRRT1 PTPRN RAMP1 SDC4 SGCB SHISA3 SHISA4 SLC10A1 SLC35C2 SMIM3 SPINT1 STX1A SYNDIG1 TEX29 TIGIT TM4SF18 TMEM106C TMEM174 TMEM207 TMEM213 TMEM248 TMEM30A TMEM52B TNFSF14 TSPO2 USP7
Entrez ID		64065	4118
HPRD ID		17836	01789
Ensembl ID		ENSG00000112378	ENSG00000172005
Uniprot IDs		Q96FX8	A0A024RE19 P21145
PDB IDs
Enriched GO Terms of Interacting Partners?
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