SEMA3F and UBA1

Data Source:
HPRD (two hybrid)

		SEMA3F	UBA1
Description		semaphorin 3F	ubiquitin like modifier activating enzyme 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Glutamatergic Synapse	Heterochromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Exosome
	Molecular Function	Semaphorin Receptor Binding Chemorepellent Activity	RNA Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding
	Biological Process	Neural Crest Cell Migration Axon Guidance Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Nerve Development Branchiomotor Neuron Axon Guidance Positive Regulation Of Cell Migration Ventral Trunk Neural Crest Cell Migration Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Negative Chemotaxis Sympathetic Ganglion Development Semaphorin-plexin Signaling Pathway Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Regulation Of Postsynapse Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Semaphorin-plexin Signaling Pathway Involved In Axon Guidance	Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Protein Ubiquitination Protein Phosphopantetheinylation Protein Modification By Small Protein Conjugation
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Hexatantalum Dodecabromide Quercetin
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS		Age at first birth ( 27089180) Age at first sexual intercourse ( 27089180) Body mass index ( 26426971 29273807) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Glaucoma ( 31959993) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29785010 31959993) Mean platelet volume ( 32888494) Morning person ( 30696823) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		7 interacting genes: NRP1 NRP2 SHBG SLC35G2 UBA1 UBC VEGFA	51 interacting genes: ABCF1 BUB3 CDC34 CDK1 CHEK1 ECHS1 GAN GRB2 HGS HSPH1 LINC01554 MGMT MTNR1A PIAS3 SEMA3F SMAD5 SUMO2 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2Q2 UBE2R2 UBE2S UBE2T UBE2U UBE2W UBE2Z UBTD2
Entrez ID		6405	7317
HPRD ID		03079	02440
Ensembl ID		ENSG00000001617	ENSG00000130985
Uniprot IDs		C9JPG5 Q13275 Q59G50	A0A024R1A3 P22314
PDB IDs			4P22 6DC6
Enriched GO Terms of Interacting Partners?
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