SH2D4A and SKAP1

Data Source:
BioGRID (two hybrid)

		SH2D4A	SKAP1
Description		SH2 domain containing 4A	src kinase associated phosphoprotein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Immunological Synapse Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction T Cell Receptor Complex Plasma Membrane Raft
	Molecular Function	Protein Binding Phosphatase Binding	Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Phosphatase Binding SH2 Domain Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Phosphatase Activity	Positive Regulation Of Cell-matrix Adhesion Adaptive Immune Response Positive Regulation Of Adaptive Immune Response Positive Regulation Of Integrin Activation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane Positive Regulation Of Leukocyte Cell-cell Adhesion
Pathways
Drugs
Diseases
GWAS		Smooth-surface caries ( 24556642) Urate levels in overweight individuals ( 25811787) Urinary albumin excretion rate in type 1 diabetes ( 24595857)	Body mass index ( 28892062 25673413) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Epithelial ovarian cancer ( 25581431) Food allergy ( 29030101) Generalized epilepsy ( 22949513) HDL cholesterol levels ( 32203549) Intelligence ( 28530673) Lean body mass ( 28552196) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Ovarian cancer ( 20852632) Peanut allergy ( 29030101) Pulse pressure ( 30578418) White blood cell count ( 32888494)
Interacting Genes		74 interacting genes: ALAS1 ARC BLOC1S2 CADPS CASK CCDC172 CCDC88B CDR2 CDR2L CEP70 CEP76 CFAP53 DBNL FCHO1 FCHSD2 FSD2 GOLGA2 GOLGA6L9 GPRASP2 GRAMD4 GRAP2 GRB2 HCLS1 HMBOX1 HOOK2 HSF2BP IKZF1 KRT40 LDOC1 LZTS2 MAGEA11 MAGEA6 MBD3L1 MEOX2 MORN3 MRFAP1 MTUS2 NECAB2 NINL NUTM1 OLIG1 PDE4DIP PICK1 PLEKHG4 PNMA1 PPP1CB PRKAR1B PSTPIP1 RINT1 SH3GL1 SH3RF1 SKAP1 SORBS2 SORBS3 SPAG5 STAM2 STX11 TACC1 TFIP11 TRAF2 TRIM23 TRIM27 TRIML2 TTC19 UBXN11 USHBP1 VPS52 WWOX YPEL2 YPEL3 ZBTB16 ZMYND12 ZNF655 ZNF774	13 interacting genes: APP BLCAP DYNLL2 FAM102A FYB1 FYN GRB2 LCK LYN PRAM1 PTPRC SH2D4A SRC
Entrez ID		63898	8631
HPRD ID		08340	05396
Ensembl ID		ENSG00000104611	ENSG00000141293
Uniprot IDs		Q9H788	Q86WV1 V9HW03
PDB IDs			1U5D
Enriched GO Terms of Interacting Partners?
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