SH2D4A and ARC

Data Source:
BioGRID (two hybrid)

		SH2D4A	ARC
Description		SH2 domain containing 4A	activity regulated cytoskeleton associated protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Acrosomal Vesicle Cytoplasm Plasma Membrane Cell Cortex Actin Cytoskeleton Early Endosome Membrane Neuronal Cell Body Dendritic Spine Membrane Raft Neuronal Ribonucleoprotein Granule Postsynaptic Density Membrane Postsynaptic Endosome Glutamatergic Synapse Extracellular Vesicle
	Molecular Function	Protein Binding Phosphatase Binding	MRNA Binding Protein Binding
	Biological Process	Negative Regulation Of Phosphatase Activity	Endocytosis Cytoskeleton Organization Endoderm Development Learning Long-term Memory Anterior/posterior Pattern Specification Cell Migration Regulation Of Cell Morphogenesis Regulation Of Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission MRNA Transport Protein Homooligomerization Long-term Synaptic Potentiation Dendritic Spine Morphogenesis Regulation Of Dendritic Spine Morphogenesis Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Vesicle-mediated Intercellular Transport Regulation Of Long-term Synaptic Potentiation Regulation Of Long-term Synaptic Depression Positive Regulation Of AMPA Receptor Activity
Pathways			NGF-stimulated transcription NGF-stimulated transcription
Drugs
Diseases
GWAS		Smooth-surface caries ( 24556642) Urate levels in overweight individuals ( 25811787) Urinary albumin excretion rate in type 1 diabetes ( 24595857)	Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Automobile speeding propensity ( 30643258)
Interacting Genes		74 interacting genes: ALAS1 ARC BLOC1S2 CADPS CASK CCDC172 CCDC88B CDR2 CDR2L CEP70 CEP76 CFAP53 DBNL FCHO1 FCHSD2 FSD2 GOLGA2 GOLGA6L9 GPRASP2 GRAMD4 GRAP2 GRB2 HCLS1 HMBOX1 HOOK2 HSF2BP IKZF1 KRT40 LDOC1 LZTS2 MAGEA11 MAGEA6 MBD3L1 MEOX2 MORN3 MRFAP1 MTUS2 NECAB2 NINL NUTM1 OLIG1 PDE4DIP PICK1 PLEKHG4 PNMA1 PPP1CB PRKAR1B PSTPIP1 RINT1 SH3GL1 SH3RF1 SKAP1 SORBS2 SORBS3 SPAG5 STAM2 STX11 TACC1 TFIP11 TRAF2 TRIM23 TRIM27 TRIML2 TTC19 UBXN11 USHBP1 VPS52 WWOX YPEL2 YPEL3 ZBTB16 ZMYND12 ZNF655 ZNF774	7 interacting genes: CSRP2 KRT15 S100P SH2D4A SPTBN4 TBX18 UBE3A
Entrez ID		63898	23237
HPRD ID		08340	12469
Ensembl ID		ENSG00000104611	ENSG00000198576
Uniprot IDs		Q9H788	Q7LC44
PDB IDs
Enriched GO Terms of Interacting Partners?
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