SKAP1 and FYB1

Data Source:
HPRD (two hybrid)

		SKAP1	FYB1
Description		src kinase associated phosphoprotein 1	FYN binding protein 1
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GO Annotations	Cellular Component	Immunological Synapse Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction T Cell Receptor Complex Plasma Membrane Raft	Nucleus Cytosol Plasma Membrane Actin Cytoskeleton Cell Junction Protein-containing Complex
	Molecular Function	Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Phosphatase Binding SH2 Domain Binding Protein-containing Complex Binding	Signaling Receptor Binding Protein Binding Lipid Binding Protein-containing Complex Binding
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Adaptive Immune Response Positive Regulation Of Adaptive Immune Response Positive Regulation Of Integrin Activation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane Positive Regulation Of Leukocyte Cell-cell Adhesion	Immune Response Integrin-mediated Signaling Pathway Biological_process T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane
Pathways			Generation of second messenger molecules Generation of second messenger molecules Signal regulatory protein family interactions
Drugs
Diseases
GWAS		Body mass index ( 28892062 25673413) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Epithelial ovarian cancer ( 25581431) Food allergy ( 29030101) Generalized epilepsy ( 22949513) HDL cholesterol levels ( 32203549) Intelligence ( 28530673) Lean body mass ( 28552196) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Ovarian cancer ( 20852632) Peanut allergy ( 29030101) Pulse pressure ( 30578418) White blood cell count ( 32888494)
Interacting Genes		13 interacting genes: APP BLCAP DYNLL2 FAM102A FYB1 FYN GRB2 LCK LYN PRAM1 PTPRC SH2D4A SRC	15 interacting genes: BCAR1 CBL CBLB ENAH EVL FASLG FYN LCP2 NCK2 SH2D1A SKAP1 SKAP2 SRC VASP WAS
Entrez ID		8631	2533
HPRD ID		05396	04107
Ensembl ID		ENSG00000141293	ENSG00000082074
Uniprot IDs		Q86WV1 V9HW03	O15117
PDB IDs		1U5D	1RI9 2GTJ 2GTO
Enriched GO Terms of Interacting Partners?
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