ABHD4 and COL4A5

Data Source:
BioGRID (two hybrid)

		ABHD4	COL4A5
Description		abhydrolase domain containing 4, N-acyl phospholipase B	collagen type IV alpha 5 chain
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Lipid Droplet	Extracellular Region Collagen Type IV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Neuromuscular Junction Collagen-containing Extracellular Matrix
	Molecular Function	Lysophospholipase Activity Protein Binding Hydrolase Activity Lysophosphatidic Acid Acyltransferase Activity Carboxylic Ester Hydrolase Activity	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Phosphatidic Acid Biosynthetic Process Lipid Catabolic Process Phosphatidylethanolamine Acyl-chain Remodeling Lipid Homeostasis N-acylphosphatidylethanolamine Metabolic Process	Neuromuscular Junction Development Extracellular Matrix Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Pathways		Acyl chain remodelling of PE	Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Regulation of expression of SLITs and ROBOs
Drugs
Diseases			Alport syndrome
GWAS		Metabolite levels ( 23823483) Microalbuminuria ( 26631737)
Interacting Genes		14 interacting genes: AURKAIP1 BNIP2 CMTM5 COL4A5 CSNK2B DERL1 DGAT2L6 HTATIP2 IGFBP5 INSIG2 PLIN3 RABAC1 REEP5 TK1	46 interacting genes: ABHD4 ANTXR2 ANXA7 APP ATP6V0B BSND CD53 CD79A CD93 CDKN1A CERS4 CLDN7 DAZAP2 DCN ELOVL4 ERGIC3 FAM209A FBLN2 FFAR2 FN1 GPX8 HABP2 KCNJ6 MATN2 MFF MMP9 MTIF3 NCR3LG1 NEMP1 NR1H2 OSM RELL2 RNF10 SAR1A SERPINE2 SLC10A4 SLC10A6 SLC16A2 SLC18A1 SLC35C2 SLC39A2 SMN1 THAP4 TK1 TMEM80 TSPO2
Entrez ID		63874	1287
HPRD ID		12406	02363
Ensembl ID		ENSG00000100439	ENSG00000188153
Uniprot IDs		Q8TB40	A7MBN3 P29400 Q49AM6
PDB IDs			5NAZ
Enriched GO Terms of Interacting Partners?
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