ABHD4 and INSIG2

Data Source:
BioGRID (two hybrid)

		ABHD4	INSIG2
Description		abhydrolase domain containing 4, N-acyl phospholipase B	insulin induced gene 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Lipid Droplet	Endoplasmic Reticulum Endoplasmic Reticulum Membrane SREBP-SCAP-Insig Complex
	Molecular Function	Lysophospholipase Activity Protein Binding Hydrolase Activity Lysophosphatidic Acid Acyltransferase Activity Carboxylic Ester Hydrolase Activity	Protein Binding Oxysterol Binding
	Biological Process	Phosphatidic Acid Biosynthetic Process Lipid Catabolic Process Phosphatidylethanolamine Acyl-chain Remodeling Lipid Homeostasis N-acylphosphatidylethanolamine Metabolic Process	Cholesterol Biosynthetic Process Sterol Biosynthetic Process Cellular Response To Insulin Stimulus SREBP Signaling Pathway SREBP-SCAP Complex Retention In Endoplasmic Reticulum
Pathways		Acyl chain remodelling of PE	Regulation of cholesterol biosynthesis by SREBP (SREBF)
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Microalbuminuria ( 26631737)	Apolipoprotein B levels ( 32203549) Cholesterol, total ( 24097068) Depression in response to interferon-based therapy in chronic hepatitis C ( 27723809) Heel bone mineral density ( 30598549 28869591) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 32203549 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731) Lumbar spine bone mineral density ( 22504420) Monobrow ( 27182965) Mosquito bite size ( 28199695) Total cholesterol levels ( 30275531)
Interacting Genes		14 interacting genes: AURKAIP1 BNIP2 CMTM5 COL4A5 CSNK2B DERL1 DGAT2L6 HTATIP2 IGFBP5 INSIG2 PLIN3 RABAC1 REEP5 TK1	46 interacting genes: ABHD4 AQP2 AQP6 ATP6V0B BIK CD40 CD79A CPLX4 CREB3L1 CYBC1 EBP FAM209A GJA8 GOLM1 GPR152 GPR37L1 GPX8 HSD17B13 IFNGR2 KIR2DL3 LAPTM5 LHFPL5 LMNA MMGT1 MUC1 NEMP1 PRLR PSCA PSMA7 PSMB1 PSMC3 PSMC5 PVR RNF5 SCAP SCN3B SLC16A10 SREBF2 STIM1 TMEM14B TMEM237 TMEM45B TMEM52B TMX2 VCP VMA21
Entrez ID		63874	51141
HPRD ID		12406	16361
Ensembl ID		ENSG00000100439	ENSG00000125629
Uniprot IDs		Q8TB40	A0A024RAI2 B4DQ23 Q9Y5U4
PDB IDs			4J82
Enriched GO Terms of Interacting Partners?
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