COL4A5 and ABHD4

Data Source:
BioGRID (two hybrid)

		COL4A5	ABHD4
Description		collagen type IV alpha 5 chain	abhydrolase domain containing 4, N-acyl phospholipase B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Neuromuscular Junction Collagen-containing Extracellular Matrix	Mitochondrion Endoplasmic Reticulum Membrane Lipid Droplet
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength	Lysophospholipase Activity Protein Binding Hydrolase Activity Lysophosphatidic Acid Acyltransferase Activity Carboxylic Ester Hydrolase Activity
	Biological Process	Neuromuscular Junction Development Extracellular Matrix Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway	Phosphatidic Acid Biosynthetic Process Lipid Catabolic Process Phosphatidylethanolamine Acyl-chain Remodeling Lipid Homeostasis N-acylphosphatidylethanolamine Metabolic Process
Pathways		Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Regulation of expression of SLITs and ROBOs	Acyl chain remodelling of PE
Drugs
Diseases		Alport syndrome
GWAS			Metabolite levels ( 23823483) Microalbuminuria ( 26631737)
Interacting Genes		46 interacting genes: ABHD4 ANTXR2 ANXA7 APP ATP6V0B BSND CD53 CD79A CD93 CDKN1A CERS4 CLDN7 DAZAP2 DCN ELOVL4 ERGIC3 FAM209A FBLN2 FFAR2 FN1 GPX8 HABP2 KCNJ6 MATN2 MFF MMP9 MTIF3 NCR3LG1 NEMP1 NR1H2 OSM RELL2 RNF10 SAR1A SERPINE2 SLC10A4 SLC10A6 SLC16A2 SLC18A1 SLC35C2 SLC39A2 SMN1 THAP4 TK1 TMEM80 TSPO2	14 interacting genes: AURKAIP1 BNIP2 CMTM5 COL4A5 CSNK2B DERL1 DGAT2L6 HTATIP2 IGFBP5 INSIG2 PLIN3 RABAC1 REEP5 TK1
Entrez ID		1287	63874
HPRD ID		02363	12406
Ensembl ID		ENSG00000188153	ENSG00000100439
Uniprot IDs		A7MBN3 P29400 Q49AM6	Q8TB40
PDB IDs		5NAZ
Enriched GO Terms of Interacting Partners?
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