SORT1 and NTS

Data Source:
HPRD (in vivo, in vitro)

		SORT1	NTS
Description		sortilin 1	neurotensin
Image
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Early Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Endosome Membrane Integral Component Of Membrane Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle Dendrite Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane Golgi Cisterna Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm	Extracellular Region Transport Vesicle Intracellular Membrane-bounded Organelle Axon Terminus
	Molecular Function	Protein Binding Nerve Growth Factor Receptor Activity Enzyme Binding Neurotensin Receptor Activity, Non-G Protein-coupled Nerve Growth Factor Binding Retromer Complex Binding	Neuropeptide Hormone Activity Protein Binding Receptor Ligand Activity Neuropeptide Receptor Binding
	Biological Process	Ossification Protein Targeting To Lysosome Post-Golgi Vesicle-mediated Transport Golgi To Endosome Transport Endocytosis G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Multicellular Organism Development Endosome To Lysosome Transport Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Myotube Differentiation Vesicle Organization Endosome Transport Via Multivesicular Body Sorting Pathway Response To Insulin Nerve Growth Factor Signaling Pathway Negative Regulation Of Fat Cell Differentiation Glucose Import Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane To Endosome Transport Negative Regulation Of Lipoprotein Lipase Activity Golgi To Lysosome Transport Positive Regulation Of Epithelial Cell Apoptotic Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway
Pathways		Golgi Associated Vesicle Biogenesis	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 27899403) Cholesterol, total ( 24097068 25961943 20686565) Chronic kidney disease ( 20383146) Cognitive ability ( 29186694) Coronary artery disease ( 21239051 24262325 26343387 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378988 21378990) Coronary heart disease x type 2 diabetes interaction ( 32541925) HDL cholesterol ( 25961943) LDL cholesterol ( 24097068 18193043 18193044 19060906 19060910 21347282 25961943 20686565) LDL cholesterol levels ( 28334899 26690388) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Low density lipoprotein cholesterol levels ( 30718733 31969989) Low density lipoprotein cholesterol levels (on statin treatment) ( 31969989) Metabolite levels ( 21909109) Metabolite levels (lipoprotein measures) ( 27005778) Myocardial infarction ( 26343387) Myocardial infarction (early onset) ( 19198609) Peripheral artery disease ( 31285632) Progranulin levels ( 21087763 29186428) Ratio of apolipoprotein A1 to apolipoprotein B ( 29084231) Response to statin therapy ( 20339536) Response to statins (LDL cholesterol change) ( 31969989) Response to statins (LDL cholesterol percent change) ( 31969989) Total cholesterol levels ( 28334899)	Metabolite levels ( 23823483)
Interacting Genes		16 interacting genes: ADGRG7 BDNF BRICD5 CNIH3 GGA1 GGA2 LRPAP1 NGF NGFR NTRK1 NTRK2 NTRK3 NTS SORCS1 SORL1 TF	10 interacting genes: ACE2 ARRB2 CPE MEP1A MFF NLN NTSR1 NTSR2 PREP SORT1
Entrez ID		6272	4922
HPRD ID		03910	08878
Ensembl ID		ENSG00000134243	ENSG00000133636
Uniprot IDs		Q99523	P30990 Q6FH20
PDB IDs		3F6K 3G2U 3G2V 4MSL 4N7E 4PO7 5MRH 5MRI 6EHO 6X3L 6X48 6X4H	2LNE 2LNF 2LNG 2LYW 2OYV 2OYW 3F6K 4PO7 5LUZ 6UP7
Enriched GO Terms of Interacting Partners?
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