RPS6 and PRKACB

Data Source:
BioGRID (two hybrid)

		RPS6	PRKACB
Description		ribosomal protein S6	protein kinase cAMP-activated catalytic subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Endoplasmic Reticulum Cytosol Polysome Small Ribosomal Subunit Membrane Cytosolic Small Ribosomal Subunit Dendrite Cytoplasmic Ribonucleoprotein Granule Cell Body Perinuclear Region Of Cytoplasm Ribonucleoprotein Complex	Nucleus Nucleoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding Protein Kinase Binding	Magnesium Ion Binding AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Placenta Development T Cell Proliferation Involved In Immune Response RRNA Processing Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Activation-induced Cell Death Of T Cells Gastrulation Positive Regulation Of Cell Population Proliferation Viral Transcription Mammalian Oogenesis Stage TOR Signaling T Cell Differentiation In Thymus Ribosomal Small Subunit Biogenesis Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Erythrocyte Development	Neural Tube Closure Stimulatory C-type Lectin Receptor Signaling Pathway Renal Water Homeostasis Protein Phosphorylation Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Blood Coagulation Protein Kinase A Signaling Activation Of Protein Kinase A Activity High-density Lipoprotein Particle Assembly Negative Regulation Of Meiotic Cell Cycle Regulation Of Protein Processing Cellular Response To Glucagon Stimulus Response To Clozapine Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation mTORC1-mediated signalling SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	PKA-mediated phosphorylation of CREB PKA-mediated phosphorylation of key metabolic factors Triglyceride catabolism PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins VEGFA-VEGFR2 Pathway CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of Adenylate Cyclase Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state CD209 (DC-SIGN) signaling MAPK6/MAPK4 signaling RET signaling HDL assembly ROBO receptors bind AKAP5 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs		Artenimol	Phosphonothreonine Fostamatinib
Diseases
GWAS		Total cholesterol levels ( 29083408)	Breast cancer (male) ( 23001122) Metabolite levels ( 23823483)
Interacting Genes		16 interacting genes: ATF4 DUX4 ERCC6 FRS2 MYOM2 NDRG1 OLFM2 PAK2 PLA2G12A PRKACB PRKCSH PTEN RPS6KB1 RPS6KB2 STAU1 UPF2	15 interacting genes: ACVR1B APPBP2 ARFGAP1 AVPI1 CSNK2A1 FBXO7 NGFR PKIA PKIB RPL27A RPS6 SPP1 TNP1 TNP2 TP73
Entrez ID		6194	5567
HPRD ID		01592	01482
Ensembl ID		ENSG00000137154	ENSG00000142875
Uniprot IDs		A2A3R6 P62753	A0A087WVC4 B1APF9 B1APG3 B2RB89 B7ZA00 P22694
PDB IDs		4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6F4P 6F4Q 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZVH 6ZVJ 7A09 7K5I
Enriched GO Terms of Interacting Partners?
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