RORB and LCOR

Data Source:
BioGRID (two hybrid)

		RORB	LCOR
Description		RAR related orphan receptor B	ligand dependent nuclear receptor corepressor
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Melatonin Receptor Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Corepressor Binding DNA Binding Transcription Corepressor Activity Protein Binding Estrogen Receptor Binding Histone Deacetylase Binding Histone Methyltransferase Binding Ubiquitin-specific Protease Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter G Protein-coupled Receptor Signaling Pathway Visual Perception Intracellular Receptor Signaling Pathway Amacrine Cell Differentiation Eye Photoreceptor Cell Development Regulation Of Circadian Rhythm Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Retinal Rod Cell Development Retinal Cone Cell Development Rhythmic Process Retina Development In Camera-type Eye Cellular Response To Retinoic Acid	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus
Pathways
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Alcohol consumption (drinks per week) ( 30643258) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Chronotype ( 30696823) Immature fraction of reticulocytes ( 32888494) Macular thickness ( 30535121) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Simvastatin-induced myopathy ( 31220337) Waist circumference ( 28552196)
Interacting Genes		36 interacting genes: ANKS1A CLOCK CRACR2A CSNK2B DELEC1 FBXO7 GAS2L2 KRTAP4-5 LCK LCOR MAP6 MED25 MID2 NCOA1 NCOA6 NME1 NME2 NPPA NRIP1 NRIP2 NSD1 PNRC1 PNRC2 PSMC4 PSMC5 RORC SCNM1 SMARCD1 SOGA1 TEKT5 TLE5 TNNI2 TSGA10IP UBE2I ZNF417 ZNF587	13 interacting genes: AR BIRC7 CEP70 ESR1 GOLGA2 HDAC1 HDAC3 HDAC4 HDAC6 KLF6 RORB TRAF1 VDR
Entrez ID		6096	84458
HPRD ID		09062	07609
Ensembl ID		ENSG00000198963	ENSG00000196233
Uniprot IDs		Q58EY0	Q96JN0
PDB IDs			2COB
Enriched GO Terms of Interacting Partners?
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