RORB and NRIP1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RORB	NRIP1
Description		RAR related orphan receptor B	nuclear receptor interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Histone Deacetylase Complex Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Speck
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Melatonin Receptor Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Estrogen Receptor Binding Nuclear Hormone Receptor Binding Glucocorticoid Receptor Binding Histone Deacetylase Binding Retinoid X Receptor Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter G Protein-coupled Receptor Signaling Pathway Visual Perception Intracellular Receptor Signaling Pathway Amacrine Cell Differentiation Eye Photoreceptor Cell Development Regulation Of Circadian Rhythm Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Retinal Rod Cell Development Retinal Cone Cell Development Rhythmic Process Retina Development In Camera-type Eye Cellular Response To Retinoic Acid	Negative Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Rupture Circadian Rhythm Lipid Storage Circadian Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus
Pathways			SUMOylation of transcription cofactors Circadian Clock Estrogen-dependent gene expression NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs			4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Alcohol consumption (drinks per week) ( 30643258) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Chronotype ( 30696823) Immature fraction of reticulocytes ( 32888494) Macular thickness ( 30535121) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Alcohol dependence ( 26365420) Birth weight ( 31043758 27680694) Blood urea nitrogen levels ( 31152163) Breast cancer ( 29059683 23535729) Chronic kidney disease ( 31152163) Cognitive performance ( 19734545) Crohn's disease ( 25489960) Depression in smokers ( 30219690) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Gastroesophageal reflux disease ( 31527586) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte counts ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27841878) White blood cell count ( 32888494)
Interacting Genes		36 interacting genes: ANKS1A CLOCK CRACR2A CSNK2B DELEC1 FBXO7 GAS2L2 KRTAP4-5 LCK LCOR MAP6 MED25 MID2 NCOA1 NCOA6 NME1 NME2 NPPA NRIP1 NRIP2 NSD1 PNRC1 PNRC2 PSMC4 PSMC5 RORC SCNM1 SMARCD1 SOGA1 TEKT5 TLE5 TNNI2 TSGA10IP UBE2I ZNF417 ZNF587	56 interacting genes: ACTN2 AGR2 AHR APP AR ARPC3 BHLHB9 BRCA1 CCDC85B CDK8 CEP70 CIB1 CTBP1 CTBP2 DNMT1 DNMT3A DNMT3B E2F1 ESR1 ESR2 ESRRA ESRRB ESRRG HDAC1 HDAC2 HDAC3 HDAC5 HNF4A JUN KAT2B LDOC1 MAP3K7 NR0B1 NR1H2 NR1H3 NR2C1 NR3C1 NR5A1 NR5A2 PKNOX2 PPARA PPARD PPARG PRMT1 RARA RORB RXRA RXRB TEX11 THRA THRB TNFRSF14 TRAF2 TULP3 VDR YWHAH
Entrez ID		6096	8204
HPRD ID		09062	03927
Ensembl ID		ENSG00000198963	ENSG00000180530
Uniprot IDs		Q58EY0	A8K171 P48552
PDB IDs			2GPO 2GPP 4S14 4S15 5NTI 5NTN 5NTW 5NU1 6FZU 6G05 6G07
Enriched GO Terms of Interacting Partners?
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