RORB and NME2

Data Source:
HPRD (in vitro, two hybrid)

		RORB	NME2
Description		RAR related orphan receptor B	NME/NM23 nucleoside diphosphate kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Intermediate Filament Focal Adhesion Lamellipodium Mitochondrial Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Melatonin Receptor Activity Sequence-specific Double-stranded DNA Binding	DNA Binding Transcription Coactivator Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Serine/threonine Kinase Activity Fatty Acid Binding Protein Binding ATP Binding Drug Binding GDP Binding Intermediate Filament Binding Enzyme Binding Identical Protein Binding Metal Ion Binding G-quadruplex DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter G Protein-coupled Receptor Signaling Pathway Visual Perception Intracellular Receptor Signaling Pathway Amacrine Cell Differentiation Eye Photoreceptor Cell Development Regulation Of Circadian Rhythm Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Retinal Rod Cell Development Retinal Cone Cell Development Rhythmic Process Retina Development In Camera-type Eye Cellular Response To Retinoic Acid	Negative Regulation Of Myeloid Leukocyte Differentiation Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process Cell Adhesion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Nucleoside Triphosphate Biosynthetic Process Positive Regulation Of Neuron Projection Development Nucleobase-containing Small Molecule Interconversion Peptidyl-histidine Phosphorylation Cellular Response To Oxidative Stress Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of Keratinocyte Differentiation Regulation Of Epidermis Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Positive Regulation Of Epithelial Cell Proliferation Response To Growth Hormone Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid
Pathways			Interconversion of nucleotide di- and triphosphates Neutrophil degranulation
Drugs			Guanosine-5'-Diphosphate
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Alcohol consumption (drinks per week) ( 30643258) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Chronotype ( 30696823) Immature fraction of reticulocytes ( 32888494) Macular thickness ( 30535121) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Height ( 20881960)
Interacting Genes		36 interacting genes: ANKS1A CLOCK CRACR2A CSNK2B DELEC1 FBXO7 GAS2L2 KRTAP4-5 LCK LCOR MAP6 MED25 MID2 NCOA1 NCOA6 NME1 NME2 NPPA NRIP1 NRIP2 NSD1 PNRC1 PNRC2 PSMC4 PSMC5 RORC SCNM1 SMARCD1 SOGA1 TEKT5 TLE5 TNNI2 TSGA10IP UBE2I ZNF417 ZNF587	18 interacting genes: BNIPL CTBP1 DNM1 GIT2 HERC3 HERC5 HERC6 MOB4 NME1 NME3 PPP2CA RAB5A RORA RORB SVIL TBXA2R TERF1 VIM
Entrez ID		6096	4831
HPRD ID		09062	01132
Ensembl ID		ENSG00000198963	ENSG00000243678
Uniprot IDs		Q58EY0	F6XY72 P22392 Q6FHN3
PDB IDs			1NSK 1NUE 3BBB 3BBC 3BBF
Enriched GO Terms of Interacting Partners?
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