RLBP1 and KLHL8

Data Source:
BioGRID (two hybrid)

		RLBP1	KLHL8
Description		retinaldehyde binding protein 1	kelch like family member 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Centrosome Cytosol Cell Body	Nucleoplasm Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	11-cis Retinal Binding Protein Binding Retinol Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Retinoid Metabolic Process Vitamin A Metabolic Process Visual Perception Response To Stimulus	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination
Pathways		The retinoid cycle in cones (daylight vision) The retinoid cycle in cones (daylight vision) Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision)
Drugs
Diseases		Newfoundland rod-cone dystrophy (NFRCD) Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS		Advanced age-related macular degeneration ( 28813576) Age-related macular degeneration (SNP x mitochondrial G12771A interaction) ( 28813576) Schizophrenia ( 28991256)	Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 29403010) Bulimia nervosa ( 23568457) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 28334899) Rosacea symptom severity ( 29771307) Total cholesterol levels ( 30275531) Triglyceride levels ( 28334899 29403010) Triglycerides ( 24097068 25961943 20686565)
Interacting Genes		4 interacting genes: APP KLHL8 RDH5 SLC9A3R1	13 interacting genes: ARMC9 ATXN1 CA8 COIL MAPK9 PNMT PPM1F RAPSN RLBP1 SULT2B1 TEX101 TP53I13 USP7
Entrez ID		6017	57563
HPRD ID		01572	13928
Ensembl ID		ENSG00000140522	ENSG00000145332
Uniprot IDs		P12271	B3KY78 Q68DU9 Q7Z330 Q9P2G9
PDB IDs		1XGG 1XGH 3HX3 3HY5 4CIZ 4CJ6
Enriched GO Terms of Interacting Partners?
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