RDX and SLC9A3R2

Data Source:
HPRD (in vitro)

		RDX	SLC9A3R2
Description		radixin	SLC9A3 regulator 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Microvillus Adherens Junction Focal Adhesion Apical Plasma Membrane Lamellipodium Filopodium T-tubule Midbody Cortical Actin Cytoskeleton Cleavage Furrow Cell Tip Extracellular Exosome Cell Periphery	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Apical Plasma Membrane Extracellular Exosome
	Molecular Function	RNA Binding Actin Binding Protein Binding Cadherin Binding Protein Kinase A Binding ATPase Binding	Signaling Receptor Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding
	Biological Process	Regulation Of Cell Shape Regulation Of Cell Size Positive Regulation Of Gene Expression Protein Kinase A Signaling Positive Regulation Of Cell Migration Regulation Of Actin Filament Bundle Assembly Regulation Of Rap Protein Signal Transduction Negative Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of GTPase Activity Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of GTPase Activity Apical Protein Localization Establishment Of Protein Localization Negative Regulation Of Cell Size Barbed-end Actin Filament Capping Establishment Of Endothelial Barrier Protein Localization To Plasma Membrane Cellular Response To Thyroid Hormone Stimulus Regulation Of Ruffle Assembly Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Adherens Junction Organization Positive Regulation Of Early Endosome To Late Endosome Transport	Protein-containing Complex Assembly Protein Localization To Plasma Membrane
Pathways		Recycling pathway of L1 Recycling pathway of L1
Drugs		1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS		Cognitive function ( 24684796) Coronary artery disease ( 32469254) Multiple sclerosis ( 31604244)	Diastolic blood pressure ( 27841878 30578418) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 30578418) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		20 interacting genes: ABCC2 ARHGDIA C1QTNF9 CALM1 CPNE1 CPNE2 CPNE4 DRD3 EZR GNA13 ICAM2 ITGB2 L1CAM LINC01554 PSME3 ROCK1 SLC9A3R1 SLC9A3R2 TSC1 VPS11	41 interacting genes: ABCC4 ACTN4 ADORA2B ADRB2 ATP2B2 CFTR DLGAP4 EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAZ TBC1D10A TRAF4 WWP2 WWTR1
Entrez ID		5962	9351
HPRD ID		01534	05946
Ensembl ID		ENSG00000137710	ENSG00000065054
Uniprot IDs		B0YJ88 P35241 Q6PKD3	Q15599
PDB IDs			2D11 2HE4 2OCS 4P0C
Enriched GO Terms of Interacting Partners?
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