RBBP7 and SAP30

Data Source:
HPRD (in vivo)

		RBBP7	SAP30
Description		RB binding protein 7, chromatin remodeling factor	Sin3A associated protein 30
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol NuRD Complex ESC/E(Z) Complex	Histone Deacetylase Complex Nucleoplasm
	Molecular Function	RNA Binding Protein Binding	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Negative Regulation Of Cell Growth CENP-A Containing Nucleosome Assembly Post-translational Protein Modification Negative Regulation Of Gene Expression, Epigenetic Response To Steroid Hormone Negative Regulation Of G0 To G1 Transition Cellular Heat Acclimation Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Skeletal Muscle Cell Differentiation
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines HATs acetylate histones RMTs methylate histone arginines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Activation of anterior HOX genes in hindbrain development during early embryogenesis Deposition of new CENPA-containing nucleosomes at the centromere Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Neddylation Transcriptional Regulation by E2F6 HCMV Early Events Potential therapeutics for SARS	HDACs deacetylate histones NoRC negatively regulates rRNA expression Potential therapeutics for SARS
Drugs
Diseases
GWAS		Refractive error ( 32231278)
Interacting Genes		34 interacting genes: APPL1 APPL2 BCL11A BCL11B BRCA1 BRMS1 BRMS1L BUB3 CREBBP CYTOR DHX30 ERCC6 ESR1 FOXK2 H3-4 H3C1 HDAC1 HDAC2 HUWE1 ING1 MBD3 MBD3L2 MTA2 NR2E3 PRKAA2 RB1 RBBP4 RBP1 SALL2 SAP30 SIN3A SUMO2 SUV39H1 TWIST1	26 interacting genes: BRMS1 BRMS1L CIR1 CYTOR H2AC16 H2BC21 H3-4 H4-16 HBP1 HDAC1 HDAC2 HTT ID3 ING1 MXD1 NCOR1 NCOR2 PCBD1 RBBP4 RBBP7 RBP1 SAMSN1 SAP30BP SIN3A YY1 ZNF395
Entrez ID		5931	8819
HPRD ID		04231	04540
Ensembl ID		ENSG00000102054	ENSG00000164105
Uniprot IDs		Q16576 Q6FHQ0	O75446
PDB IDs		3CFS 3CFV	2KDP
Enriched GO Terms of Interacting Partners?
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