RBBP7 and BCL11B

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RBBP7	BCL11B
Description		RB binding protein 7, chromatin remodeling factor	BAF chromatin remodeling complex subunit BCL11B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol NuRD Complex ESC/E(Z) Complex	Nucleus Neuron Projection
	Molecular Function	RNA Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Negative Regulation Of Cell Growth CENP-A Containing Nucleosome Assembly Post-translational Protein Modification Negative Regulation Of Gene Expression, Epigenetic Response To Steroid Hormone Negative Regulation Of G0 To G1 Transition Cellular Heat Acclimation Regulation Of Signal Transduction By P53 Class Mediator	Keratinocyte Development Epithelial Cell Morphogenesis Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Regulation Of Keratinocyte Proliferation Regulation Of Lipid Metabolic Process Striatal Medium Spiny Neuron Differentiation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Post-embryonic Camera-type Eye Development T Cell Differentiation In Thymus T Cell Receptor V(D)J Recombination Hematopoietic Stem Cell Migration Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Positive T Cell Selection Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Thymus Development Olfactory Bulb Axon Guidance Lymphoid Lineage Cell Migration Into Thymus
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines HATs acetylate histones RMTs methylate histone arginines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Activation of anterior HOX genes in hindbrain development during early embryogenesis Deposition of new CENPA-containing nucleosomes at the centromere Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Neddylation Transcriptional Regulation by E2F6 HCMV Early Events Potential therapeutics for SARS
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Adult body size ( 32376654) Adventurousness ( 30643258) Airway wall thickness ( 25517131) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Aortic stiffness ( 22068335) Bipolar disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Corneal curvature ( 22969067) Diastolic blood pressure night-to-day ratio in hypertension ( 29973135) Hematocrit ( 32888494) Hemoglobin ( 32888494) Metabolite levels ( 23823483) Red blood cell count ( 32888494) Schizophrenia ( 28991256 25056061 29483656 30285260) Staphylococcus aureus infection ( 24847357) Systolic blood pressure night-to-day ratio in hypertension ( 29973135)
Interacting Genes		34 interacting genes: APPL1 APPL2 BCL11A BCL11B BRCA1 BRMS1 BRMS1L BUB3 CREBBP CYTOR DHX30 ERCC6 ESR1 FOXK2 H3-4 H3C1 HDAC1 HDAC2 HUWE1 ING1 MBD3 MBD3L2 MTA2 NR2E3 PRKAA2 RB1 RBBP4 RBP1 SALL2 SAP30 SIN3A SUMO2 SUV39H1 TWIST1	9 interacting genes: CBX5 MBD3 MTA2 NR2F1 NR2F2 RBBP4 RBBP7 SP1 SUV39H1
Entrez ID		5931	64919
HPRD ID		04231	05950
Ensembl ID		ENSG00000102054	ENSG00000127152
Uniprot IDs		Q16576 Q6FHQ0	L8B567 L8B7P7 L8B862 L8B8F6 Q9C0K0
PDB IDs		3CFS 3CFV
Enriched GO Terms of Interacting Partners?
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