RBBP6 and ZBTB38

Data Source:
BioGRID (pull down, enzymatic study)
HPRD (two hybrid)

		RBBP6	ZBTB38
Description		RB binding protein 6, ubiquitin ligase	zinc finger and BTB domain containing 38
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GO Annotations	Cellular Component	Chromosome Nucleolus Centrosome Cytosol Nuclear Speck Protein-containing Complex	Nucleus Nucleoplasm Blood Microparticle
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Methyl-CpG Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Protein Polyubiquitination In Utero Embryonic Development DNA Replication Regulation Of DNA Replication MRNA Processing Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Multicellular Organism Growth Embryonic Organ Development Somite Development	Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 28892062) Body size at age 10 ( 32376654) Brain structure ( 20171287) Chronotype ( 30696823) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)	Advanced glycation end-product levels ( 26915486) Apolipoprotein A1 levels ( 32203549) Asthma ( 30929738 32296059) Asthma (childhood onset) ( 30929738) Blond vs. brown/black hair color ( 30531825) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Breast cancer ( 29059683) Brown vs. black hair color ( 30531825) Chronic obstructive pulmonary disease ( 30804561) Crohn's disease ( 28067908) Diastolic blood pressure ( 27618447) Estimated glomerular filtration rate ( 31152163) Hair color ( 29662168) Heel bone mineral density ( 30598549) Height ( 21998595 28552196 20881960 25282103 25429064 19396169 19343178 19893584 23563607 31562340 28270201 18391950 18391951 18391952 18193045 20189936) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Infant length ( 25281659) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Male-pattern baldness ( 28196072) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 24076602) Myopia ( 27182965) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Offspring birth weight ( 31043758) Physiological traits ( 31902109) Prion diseases ( 22210626) Prostate cancer ( 21743467) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Pulmonary function in asthmatics ( 25221879) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Serum total protein level ( 29403010) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27618447) Waist circumference ( 25673412) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 25673412 28448500) Weight ( 28552196)
Interacting Genes		40 interacting genes: ACOT13 ANAPC16 APOH ASGR1 CAPZA2 CASK CD81 CLK1 ETS1 EVA1C FAAP24 FBXO7 GLUL GRB2 HP KHDRBS3 LINC00305 LRCH4 MAD2L2 MDM2 MIR19A MIR19B1 NDUFB9 NEK6 PIAS1 PLG RB1 RBP4 RCC1L RPS14 SMN1 SPP1 TP53 TPT1 UBE2I UPF3B VAV2 YBX1 ZBTB38 ZFYVE9	17 interacting genes: CBFA2T3 CCDC136 EHMT2 ERCC6 FSD2 KRT40 KRTAP10-7 KRTAP10-9 LZTS2 MTUS2 MYBPH PDE4DIP RALBP1 RBBP6 TRAPPC2 TRIM41 TSGA10
Entrez ID		5930	253461
HPRD ID		02964	10985
Ensembl ID		ENSG00000122257	ENSG00000177311
Uniprot IDs		Q7Z6E9	Q8NAP3 Q9H6F0
PDB IDs		2C7H 2YSA 2YUR 3ZTG 6E5X	6E93 6E94
Enriched GO Terms of Interacting Partners?
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