ZBTB38 and CBFA2T3

Data Source:
BioGRID (two hybrid)

		ZBTB38	CBFA2T3
Description		zinc finger and BTB domain containing 38	CBFA2/RUNX1 partner transcriptional co-repressor 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Blood Microparticle	Golgi Membrane Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Methyl-CpG Binding Protein Homodimerization Activity Metal Ion Binding	Transcription Corepressor Activity Protein Binding Metal Ion Binding
	Biological Process	Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Response To Hypoxia Transcription, DNA-templated Negative Regulation Of Cell Population Proliferation Granulocyte Differentiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Aerobic Respiration
Pathways
Drugs
Diseases
GWAS		Advanced glycation end-product levels ( 26915486) Apolipoprotein A1 levels ( 32203549) Asthma ( 30929738 32296059) Asthma (childhood onset) ( 30929738) Blond vs. brown/black hair color ( 30531825) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Breast cancer ( 29059683) Brown vs. black hair color ( 30531825) Chronic obstructive pulmonary disease ( 30804561) Crohn's disease ( 28067908) Diastolic blood pressure ( 27618447) Estimated glomerular filtration rate ( 31152163) Hair color ( 29662168) Heel bone mineral density ( 30598549) Height ( 21998595 28552196 20881960 25282103 25429064 19396169 19343178 19893584 23563607 31562340 28270201 18391950 18391951 18391952 18193045 20189936) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Infant length ( 25281659) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Male-pattern baldness ( 28196072) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 24076602) Myopia ( 27182965) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Offspring birth weight ( 31043758) Physiological traits ( 31902109) Prion diseases ( 22210626) Prostate cancer ( 21743467) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Pulmonary function in asthmatics ( 25221879) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Serum total protein level ( 29403010) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27618447) Waist circumference ( 25673412) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 25673412 28448500) Weight ( 28552196)	Annualised percent change of cerebrospinal fluid AB1-42 levels ( 31370031) Carotid intima media thickness ( 30510157) Carotid intima media thickness (mean) ( 31801372) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Hair color ( 26926045) Hemoglobin levels ( 32327693) Immature fraction of reticulocytes ( 32888494) Levodopa-induced dyskinesia in levodopa treated Parkinson's disease ( 32733355) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Red cell distribution width ( 32888494) Red vs. brown/black hair color ( 30531825) Social autistic-like traits ( 24133439) Vitiligo ( 27723757)
Interacting Genes		17 interacting genes: CBFA2T3 CCDC136 EHMT2 ERCC6 FSD2 KRT40 KRTAP10-7 KRTAP10-9 LZTS2 MTUS2 MYBPH PDE4DIP RALBP1 RBBP6 TRAPPC2 TRIM41 TSGA10	23 interacting genes: ARHGEF6 CBFA2T2 CHRM4 EPM2AIP1 GAS8 GATAD2A GMEB2 HDAC1 HDAC3 MATN2 PIN1 PRKAR2A RTN4IP1 RUNX1 RUNX1T1 SEC24A TCF3 VPS37C ZBTB33 ZBTB38 ZBTB4 ZBTB47 ZNF652
Entrez ID		253461	863
HPRD ID		10985	04847
Ensembl ID		ENSG00000177311	ENSG00000129993
Uniprot IDs		Q8NAP3 Q9H6F0	O75081
PDB IDs		6E93 6E94
Enriched GO Terms of Interacting Partners?
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