RBBP6 and ANAPC16

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RBBP6	ANAPC16
Description		RB binding protein 6, ubiquitin ligase	anaphase promoting complex subunit 16
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GO Annotations	Cellular Component	Chromosome Nucleolus Centrosome Cytosol Nuclear Speck Protein-containing Complex	Kinetochore Condensed Chromosome Kinetochore Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Protein Polyubiquitination In Utero Embryonic Development DNA Replication Regulation Of DNA Replication MRNA Processing Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Multicellular Organism Growth Embryonic Organ Development Somite Development	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Cell Division Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 28892062) Body size at age 10 ( 32376654) Brain structure ( 20171287) Chronotype ( 30696823) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)	Height ( 31562340) Refractive error ( 32231278)
Interacting Genes		40 interacting genes: ACOT13 ANAPC16 APOH ASGR1 CAPZA2 CASK CD81 CLK1 ETS1 EVA1C FAAP24 FBXO7 GLUL GRB2 HP KHDRBS3 LINC00305 LRCH4 MAD2L2 MDM2 MIR19A MIR19B1 NDUFB9 NEK6 PIAS1 PLG RB1 RBP4 RCC1L RPS14 SMN1 SPP1 TP53 TPT1 UBE2I UPF3B VAV2 YBX1 ZBTB38 ZFYVE9	2 interacting genes: HSF2BP RBBP6
Entrez ID		5930	119504
HPRD ID		02964	12554
Ensembl ID		ENSG00000122257	ENSG00000166295
Uniprot IDs		Q7Z6E9	A0A087WUN5 C5H3H2 Q96DE5
PDB IDs		2C7H 2YSA 2YUR 3ZTG 6E5X	4RG6 4RG9 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5
Enriched GO Terms of Interacting Partners?
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