ANAPC16

Description		anaphase promoting complex subunit 16
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GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Cell Division Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects
Drugs
Diseases
GWAS		Height ( 31562340) Refractive error ( 32231278)
Novel Interacting Genes		1 novel interacting genes: OIT3
Interacting Genes		2 interacting genes: HSF2BP RBBP6
Entrez ID		119504
HPRD ID		12554
Ensembl ID		ENSG00000166295
Uniprot IDs		A0A087WUN5 C5H3H2 Q96DE5
PDB IDs		4RG6 4RG9 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5
Enriched GO Terms of Interacting Partners?
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