KDM5A and CCT6A

Data Source:
BioGRID (two hybrid)

		KDM5A	CCT6A
Description		lysine demethylase 5A	chaperonin containing TCP1 subunit 6A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Cytoplasm Cytosol Chaperonin-containing T-complex Microtubule Extracellular Exosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Histone Demethylase Activity Histone Demethylase Activity (H3-trimethyl-K4 Specific) Histone Demethylase Activity (H3-dimethyl-K4 Specific) Methylated Histone Binding Histone Binding Dioxygenase Activity	RNA Binding Protein Binding ATP Binding Protein Folding Chaperone Unfolded Protein Binding WD40-repeat Domain Binding
	Biological Process	Chromatin Remodeling Spermatogenesis Male Gonad Development Circadian Regulation Of Gene Expression Histone H3-K4 Demethylation Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Positive Regulation Of Transcription, DNA-templated Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Histone Deacetylase Activity	Protein Folding Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		HDMs demethylate histones	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases
GWAS		Body mass index ( 26426971) Pulse pressure ( 27841878)	Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31015462) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Systolic blood pressure ( 30224653)
Interacting Genes		11 interacting genes: CCT6A ESR1 H3-4 H3C15 LMO2 NR3C1 RARA RB1 RBL1 TBP VDR	15 interacting genes: DUX4 ERCC6 IMPA2 KDM5A LINC01554 MLX MYBPC2 PARP4 PTEN SGCG SUMO2 SUMO4 SUPT16H TRIM31 TTN
Entrez ID		5927	908
HPRD ID		08915	00089
Ensembl ID		ENSG00000073614	ENSG00000146731
Uniprot IDs		P29375	A0A024RDL1 P40227
PDB IDs		2JXJ 2KGG 2KGI 3GL6 5C11 5CEH 5E6H 5ISL 5IVB 5IVC 5IVE 5IVF 5IVJ 5IVV 5IVY 5IW0 5IWF 5K4L 5V9P 5V9T 6BGU 6BGV 6BGW 6BGX 6BGY 6BGZ 6BH0 6BH1 6BH2 6BH3 6BH4 6BH5 6DQ4 6DQ5 6DQ6 6DQ7 6DQ8 6DQ9 6DQA 6DQB 6DQC 6DQD 6DQE 6DQF	6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8
Enriched GO Terms of Interacting Partners?
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