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PLEKHF2 and P2RX7
Data Source:
BioGRID
(two hybrid)
PLEKHF2
P2RX7
Description
pleckstrin homology and FYVE domain containing 2
purinergic receptor P2X 7
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum
Transport Vesicle
Early Endosome Membrane
Integral Component Of Nuclear Inner Membrane
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Membrane
Bleb
Postsynapse
Molecular Function
Protein Binding
Phosphatidylinositol Binding
Metal Ion Binding
Lipopolysaccharide Binding
Purinergic Nucleotide Receptor Activity
Extracellularly ATP-gated Cation Channel Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Identical Protein Binding
Biological Process
Protein Transport
Regulation Of Sodium Ion Transport
Response To Ischemia
Cell Surface Receptor Signaling Pathway
Blood Coagulation
Positive Regulation Of Calcium Ion Transport Into Cytosol
Positive Regulation Of Gene Expression
Plasma Membrane Phospholipid Scrambling
Sensory Perception Of Pain
Positive Regulation Of Bone Mineralization
Bleb Assembly
Positive Regulation Of Interleukin-1 Beta Production
Response To ATP
Positive Regulation Of Ion Transmembrane Transport
Calcium-mediated Signaling Using Extracellular Calcium Source
Purinergic Nucleotide Receptor Signaling Pathway
Negative Regulation Of MAPK Cascade
Negative Regulation Of Bone Resorption
Negative Regulation Of Cell Volume
Positive Regulation Of Glycolytic Process
Pore Complex Assembly
Positive Regulation Of Cytoskeleton Organization
Regulation Of Killing Of Cells Of Other Organism
Membrane Depolarization
Excitatory Postsynaptic Potential
Calcium Ion Transmembrane Transport
Cellular Response To ATP
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Bleb Assembly
Cell Surface Receptor Signaling Pathway Involved In Cell-cell Signaling
Pathways
Elevation of cytosolic Ca2+ levels
Platelet homeostasis
The NLRP3 inflammasome
The NLRP3 inflammasome
Purinergic signaling in leishmaniasis infection
Drugs
Promethazine
Diseases
GWAS
Radiation response (
20923822
)
Birth weight (
31043758
)
Chronic obstructive pulmonary disease-related biomarkers (
23144326
)
Interacting Genes
168 interacting genes:
ABCG4
ACY3
ADAP1
AIDA
AIMP2
ANO9
APP
APPL1
ARID4B
ARL14EP
ASPH
BARHL2
BCAS2
BCAS3
BEND7
BLOC1S6
BOD1
BRD7
BSCL2
C11orf45
C1orf35
C3
CAVIN2
CBX8
CCDC146
CCDC172
CCDC25
CCDC85B
CDC20B
CEP44
CERK
CGGBP1
CHCHD2
CHIC2
COX5B
CRYBA1
DAZAP2
DMRT3
DNAAF11
DOCK2
DOCK3
DPPA4
DRAP1
DTX2
DUSP4
DUT
EIF3C
EML2
EXOC7
FAH
FBXO28
FBXW5
FGF13
FHL3
FLNA
FRMD8
GAGE12G
GAGE2E
GEM
GFER
GLUL
GNMT
GPBP1
GPBP1L1
GRAMD4
GTPBP2
HEBP2
HSPB7
INO80
KCNAB3
KRTAP10-10
KRTAP5-4
L3MBTL3
LDOC1
MAGI2
MAP2K1
MAX
MBIP
MBP
MEAF6
MFAP1
MIDN
MPP4
MRI1
NDUFA5
NFIA
NONO
NPM2
NSD2
NUDT2
NUTM1
P2RX7
PACSIN1
PAK1IP1
PDK4
PIK3R3
PPCDC
PPP1R18
PRDM14
PRKAG1
PRKAR1A
PRPSAP1
PTPN3
PWWP2A
RAB28
RABAC1
RADX
RARA
RASGEF1B
RGS10
RGS8
RPAP2
RPE
RPRM
RPS21
RSPO2
RTN1
RTN3
RTN4
S100A1
S100A13
SAMD11
SCYL1
SEC14L4
SEPTIN2
SEPTIN5
SEPTIN6
SETBP1
SFN
SNRNP35
SOST
SPATA24
SPEF1
SPON2
STAMBPL1
SYT16
TBCEL
TBX3
TCEANC
THAP10
THG1L
TNFAIP8
TNFAIP8L1
TP53BP2
TRAF6
TRAM1L1
TRAPPC3
TRIAP1
TRIM22
TSC22D3
TTC9C
TXNL4B
UBE2Z
UGP2
USF1
XCR1
XRN2
YIF1A
YY1
ZBTB6
ZDHHC24
ZFYVE26
ZNF165
ZNF250
ZNF263
ZNF398
ZNF439
ZNF581
18 interacting genes:
ACTB
CASK
CYSRT1
EFEMP2
EFNB3
EMP3
HSF2BP
KRT31
KRT34
KRTAP10-8
NBPF19
NOTCH2NLA
PANX1
PLEKHF2
SVIL
TM9SF1
TRIM27
ZNF655
Entrez ID
79666
5027
HPRD ID
15147
03977
Ensembl ID
ENSG00000175895
ENSG00000089041
Uniprot IDs
Q9H8W4
Q99572
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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