RAG2 and IPO5

Data Source:
HPRD (in vitro)

		RAG2	IPO5
Description		recombination activating 2	importin 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm DNA Recombinase Complex	Nucleus Nuclear Pore Nucleolus Cytoplasm Membrane
	Molecular Function	Chromatin Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Methylated Histone Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Sequence-specific DNA Binding Ubiquitin Protein Ligase Activity Phosphatidylinositol-3,5-bisphosphate Binding	RNA Binding GTPase Inhibitor Activity Protein Binding Nuclear Localization Sequence Binding Small GTPase Binding Nuclear Import Signal Receptor Activity
	Biological Process	B Cell Lineage Commitment Pre-B Cell Allelic Exclusion B Cell Homeostatic Proliferation T Cell Lineage Commitment Chromatin Organization Protein Ubiquitination B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination Defense Response To Bacterium Positive Regulation Of Organ Growth	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Viral Process Negative Regulation Of GTPase Activity Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Response To Amino Acid Stimulus
Pathways		Interleukin-7 signaling MAPK6/MAPK4 signaling	vRNP Assembly
Drugs
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Rheumatoid arthritis ( 24390342)	Peripheral artery disease ( 26488411) Smooth-surface caries ( 24556642)
Interacting Genes		3 interacting genes: IPO5 RAG1 SKP2	26 interacting genes: ACD BHLHB9 CAB39 CDC42 DPPA3 DTNBP1 H1-0 NUP153 NUP214 NUP62 NUP98 PTEN RAG2 RAN RANBP2 RPL13 RPL23 RPL23A RPL5 RPL7 RPS7 SRP19 SUMO2 TERF1 TINF2 WASL
Entrez ID		5897	3843
HPRD ID		08913	03597
Ensembl ID		ENSG00000175097	ENSG00000065150
Uniprot IDs		P55895	B3KWG6 O00410 Q9BVS9
PDB IDs			6XTE 6XU2
Enriched GO Terms of Interacting Partners?
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