RAD17 and POLE

Data Source:
HPRD (in vivo, in vitro)

		RAD17	POLE
Description		RAD17 checkpoint clamp loader component	DNA polymerase epsilon, catalytic subunit
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Rad17 RFC-like Complex	Nucleus Nucleoplasm Plasma Membrane Epsilon DNA Polymerase Complex
	Molecular Function	Chromatin Binding DNA Clamp Loader Activity Protein Binding ATP Binding	Nucleotide Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Single-stranded DNA 3'-5' Exodeoxyribonuclease Activity 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Negative Regulation Of DNA Replication Intra-S DNA Damage Checkpoint Mitotic DNA Replication Checkpoint Regulation Of Phosphorylation Regulation Of Signal Transduction By P53 Class Mediator	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication Initiation Leading Strand Elongation Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication DNA Replication Proofreading Embryonic Organ Development Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs			Cladribine
Diseases
GWAS		Blood urea nitrogen levels ( 31152163)	Body mass index ( 26426971) Metabolite levels ( 23823483) Urate levels in overweight individuals ( 25811787)
Interacting Genes		15 interacting genes: ATM ATR HUS1 MCM7 POLE PRKDC PRMT6 RAD1 RAD9A RAD9B RFC2 RFC3 RFC4 SNU13 USP20	12 interacting genes: ABHD16A GINS4 MDM2 PCNA POLA1 POLD4 POLE2 POLE4 RAD17 STK19 TOPBP1 XRCC5
Entrez ID		5884	5426
HPRD ID		09124	07177
Ensembl ID		ENSG00000152942	ENSG00000177084
Uniprot IDs		O75943	Q07864
PDB IDs			5VBN
Enriched GO Terms of Interacting Partners?
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