RAB3B and PIGR

Data Source:
HPRD (in vivo, in vitro)

		RAB3B	PIGR
Description		RAB3B, member RAS oncogene family	polymeric immunoglobulin receptor
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GO Annotations	Cellular Component	Cytoplasm Endosome Golgi Apparatus Cytosol Plasma Membrane Synaptic Vesicle Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Dopaminergic Synapse Anchored Component Of Synaptic Vesicle Membrane	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Azurophil Granule Membrane Receptor Complex Extracellular Exosome Secretory IgA Immunoglobulin Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Myosin V Binding	Polymeric Immunoglobulin Receptor Activity Transmembrane Signaling Receptor Activity
	Biological Process	Vesicle Docking Involved In Exocytosis Protein Secretion Regulation Of Exocytosis Antigen Processing And Presentation Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein Localization To Plasma Membrane Regulation Of Vesicle Size Regulation Of Synaptic Vesicle Cycle	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Retina Homeostasis Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Epidermal Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway Receptor Clustering Neutrophil Degranulation
Pathways		RAB geranylgeranylation	Neutrophil degranulation
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494)	Blood protein levels ( 30072576 29875488) Coronary atherosclerosis (increased number of diseased vessels) (traffic exposure interaction) ( 28355232) Inflammatory bowel disease ( 23128233) Metabolite levels ( 23823483) Precuneus cortex volume ( 31530798)
Interacting Genes		16 interacting genes: ACVR1 CALM1 CALM2 CALM3 CHM GDI1 PIGR RABIF RIMS2 RPH3A RPH3AL SGSM2 SMAD1 SMAD4 TGFBR1 VRTN	4 interacting genes: AP1M1 CCL5 CD79A RAB3B
Entrez ID		5865	5284
HPRD ID		01540	01436
Ensembl ID		ENSG00000169213	ENSG00000162896
Uniprot IDs		P20337	P01833
PDB IDs		3DZ8	1XED 2OCW 3CHN 3CM9 5D4K 6KXS 6LX3 6LXW 6UE7 6UE8 6UE9 6UEA
Enriched GO Terms of Interacting Partners?
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