PIGR and AP1M1

Data Source:
HPRD (in vivo)

		PIGR	AP1M1
Description		polymeric immunoglobulin receptor	adaptor related protein complex 1 subunit mu 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Azurophil Granule Membrane Receptor Complex Extracellular Exosome Secretory IgA Immunoglobulin Complex	Golgi Membrane Lysosomal Membrane Cytosol Plasma Membrane Membrane Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Specific Granule Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Polymeric Immunoglobulin Receptor Activity Transmembrane Signaling Receptor Activity	Protein Binding Clathrin Adaptor Activity
	Biological Process	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Retina Homeostasis Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Epidermal Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway Receptor Clustering Neutrophil Degranulation	Intracellular Protein Transport Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Organization Endosome To Melanosome Transport Neutrophil Degranulation Regulation Of Defense Response To Virus By Virus
Pathways		Neutrophil degranulation	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Coronary atherosclerosis (increased number of diseased vessels) (traffic exposure interaction) ( 28355232) Inflammatory bowel disease ( 23128233) Metabolite levels ( 23823483) Precuneus cortex volume ( 31530798)	Coronary artery disease ( 33020668)
Interacting Genes		4 interacting genes: AP1M1 CCL5 CD79A RAB3B	103 interacting genes: AMOT AP1M2 AP2B1 ARFRP1 ARL6IP4 ARNT2 ATF4 AXIN2 BACH2 BCAR3 BRCA1 C7orf57 CASP8 CCDC33 CEP57L1 CORO7 CTLA4 DCX DISC1 DVL2 DZIP3 EFEMP2 EHD2 ENTR1 ETV6 EVI5L FAM219B FAM9B FKBP7 FXR1 FXR2 GAK GCSAM GRIN2A GRIN2B HNRNPC HOOK2 IKZF1 KIF13A KIF24 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 LAMP1 LDOC1 LNX1 LRATD2 LRMDA LZTS1 LZTS2 MDK MEA1 MID2 MTF1 MYOD1 NECAB1 NKAP NKAPD1 OLIG3 PAX6 PHC2 PICK1 PIGR PNMA5 PURB RAPGEF3 RNF19B ROPN1 RP9 RSPH14 RUNDC3A SDCBP2 SELP SLC2A4 SP4 SPATA6 SRPK2 SSX2IP TEPSIN TFIP11 TGOLN2 THAP6 TIFA TNIP1 TRIM27 TRIM41 VAMP4 VANGL2 ZBTB14 ZBTB3 ZBTB43 ZBTB44 ZBTB8A ZCCHC17 ZNF19 ZNF219 ZNF276 ZNF552 ZNF655 ZNF8 ZRANB1 ZSCAN16
Entrez ID		5284	8907
HPRD ID		01436	04639
Ensembl ID		ENSG00000162896	ENSG00000072958
Uniprot IDs		P01833	A0A024R7K8 B3KNH5 Q59EK3 Q9BXS5
PDB IDs		1XED 2OCW 3CHN 3CM9 5D4K 6KXS 6LX3 6LXW 6UE7 6UE8 6UE9 6UEA
Enriched GO Terms of Interacting Partners?
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