WIZ and EHMT1

Data Source:
BioGRID (biochemical, affinity chromatography technology)
HPRD (in vivo)

		WIZ	EHMT1
Description		WIZ zinc finger	euchromatic histone lysine methyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Midbody Extracellular Exosome	Nucleus Nucleoplasm Chromosome Nuclear Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Corepressor Binding Protein Binding Protein-containing Complex Binding Metal Ion Binding Histone Methyltransferase Binding	RNA Polymerase II Transcription Corepressor Binding P53 Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Histone Methyltransferase Activity (H3-K27 Specific) C2H2 Zinc Finger Domain Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nuclear Cell Cycle DNA Replication Protein Stabilization	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Organization Histone Methylation Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Negative Regulation Of Transcription, DNA-templated Regulation Of Embryonic Development Histone H3-K9 Methylation Response To Fungicide Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation Positive Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6
Drugs
Diseases			Kleefstra syndrome; 9q Subtelomeric deletion syndrome
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494) Monocyte percentage of white cells ( 32888494)	Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Metabolite levels ( 23823483)
Interacting Genes		16 interacting genes: C8orf33 CDKN1A CRBN DOK5 EHMT1 EHMT2 OSGEP PIN1 RCC1 RPP14 RPS10 SMN1 SUV39H1 SUV39H2 TK1 TSC22D1	13 interacting genes: ATXN1 DNMT3A EED EZH2 H3-4 H3C1 LIG1 LZTR1 PCBD1 SUMO2 TP53 TRIM15 WIZ
Entrez ID		58525	79813
HPRD ID		11686	07383
Ensembl ID		ENSG00000011451	ENSG00000181090
Uniprot IDs		A0A2R8YFV2 M0QXA7 O95785	A0A1B0GV09 Q9H9B1
PDB IDs			2IGQ 2RFI 3B7B 3B95 3FPD 3HNA 3MO0 3MO2 3MO5 3SW9 3SWC 4I51 5TTG 5TUZ 5V9J 5VSD 5VSF 6BY9 6MBO 6MBP
Enriched GO Terms of Interacting Partners?
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