EHMT1 and LIG1

Data Source:
BioGRID (enzymatic study)

		EHMT1	LIG1
Description		euchromatic histone lysine methyltransferase 1	DNA ligase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Body	Nucleus Nucleoplasm Cytoplasm Mitochondrion Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Transcription Corepressor Binding P53 Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Histone Methyltransferase Activity (H3-K27 Specific) C2H2 Zinc Finger Domain Binding	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity ATP Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Organization Histone Methylation Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Negative Regulation Of Transcription, DNA-templated Regulation Of Embryonic Development Histone H3-K9 Methylation Response To Fungicide Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation Positive Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator	DNA Ligation Lagging Strand Elongation DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Anatomical Structure Morphogenesis V(D)J Recombination Cell Division DNA Biosynthetic Process Okazaki Fragment Processing Involved In Mitotic DNA Replication
Pathways		Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6	POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Processive synthesis on the C-strand of the telomere Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER Processive synthesis on the lagging strand
Drugs			Bleomycin
Diseases		Kleefstra syndrome; 9q Subtelomeric deletion syndrome	DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: ATXN1 DNMT3A EED EZH2 H3-4 H3C1 LIG1 LZTR1 PCBD1 SUMO2 TP53 TRIM15 WIZ	12 interacting genes: CSNK2A1 DCAF7 EHMT1 EHMT2 HSPB1 INPP1 MRE11 PCNA PRKCB RGS2 TUBB3 UHRF1
Entrez ID		79813	3978
HPRD ID		07383	00534
Ensembl ID		ENSG00000181090	ENSG00000105486
Uniprot IDs		A0A1B0GV09 Q9H9B1	B4DM52 F5GZ28 P18858
PDB IDs		2IGQ 2RFI 3B7B 3B95 3FPD 3HNA 3MO0 3MO2 3MO5 3SW9 3SWC 4I51 5TTG 5TUZ 5V9J 5VSD 5VSF 6BY9 6MBO 6MBP	1X9N 5YY9 6P09 6P0A 6P0B 6P0C 6P0D 6P0E 6Q1V
Enriched GO Terms of Interacting Partners?
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