BBS2 and CES1

Data Source:
BioGRID (affinity chromatography technology)

		BBS2	CES1
Description		Bardet-Biedl syndrome 2	carboxylesterase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Microvillus Membrane Motile Cilium Stereocilium BBSome Ciliary Basal Body Neuron Projection Ciliary Membrane	Extracellular Space Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Lipid Droplet Cytosol
	Molecular Function	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding	Sterol Esterase Activity Triglyceride Lipase Activity Methylumbelliferyl-acetate Deacetylase Activity Carboxylic Ester Hydrolase Activity Methyl Indole-3-acetate Esterase Activity
	Biological Process	Sperm Axoneme Assembly Visual Perception Protein Localization Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Striatum Development Hippocampus Development Cerebral Cortex Development Adult Behavior Melanosome Transport Protein Localization To Organelle Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Vasodilation Golgi To Plasma Membrane Protein Transport Fat Cell Differentiation Photoreceptor Cell Maintenance Brain Morphogenesis Cartilage Development Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Non-motile Cilium Assembly	Angiotensin Maturation Cholesterol Biosynthetic Process Xenobiotic Metabolic Process Cholesterol Metabolic Process Response To Toxic Substance Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Lipid Catabolic Process Epithelial Cell Differentiation Cholesterol Homeostasis Reverse Cholesterol Transport Medium-chain Fatty Acid Metabolic Process Regulation Of Bile Acid Biosynthetic Process Cellular Response To Cholesterol Cellular Response To Low-density Lipoprotein Particle Stimulus Cholesterol Ester Hydrolysis Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process Regulation Of Bile Acid Secretion
Pathways		BBSome-mediated cargo-targeting to cilium	Metabolism of Angiotensinogen to Angiotensins Phase I - Functionalization of compounds
Drugs			Tacrine Meperidine Levocarnitine Dextropropoxyphene Cocaine Naloxone Diamorphine Probucol Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl Ester Cholic Acid 4-Piperidino-Piperidine N-acetyl-alpha-neuraminic acid Thenoyltrifluoroacetone Cyclandelate Avasimibe (1R)-1,2,2-trimethylpropyl (R)-methylphosphinate (1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOL
Diseases		Bardet-Biedl syndrome (BBS)
GWAS			Response to dabigatran etexilate treatment ( 23467860)
Interacting Genes		15 interacting genes: BHMT EEF1A1 EPAS1 EXOC7 FHOD1 FNDC3B HNRNPF HSCB KRT18 LMO4 MDFI NRF1 PAX2 PSME3 RBPMS	10 interacting genes: BMPR2 CREB3 CYSRT1 GORAB GUSB KPRP PDZK1IP1 PLSCR4 SAR1A VENTX
Entrez ID		583	1066
HPRD ID		05855	00268
Ensembl ID		ENSG00000125124	ENSG00000198848
Uniprot IDs		Q9BXC9	P23141
PDB IDs			1MX1 1MX5 1MX9 1YA4 1YA8 1YAH 1YAJ 2DQY 2DQZ 2DR0 2H7C 2HRQ 2HRR 3K9B 4AB1 5A7F 5A7G 5A7H
Enriched GO Terms of Interacting Partners?
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