BBS2 and BHMT

Data Source:
BioGRID (two hybrid)

		BBS2	BHMT
Description		Bardet-Biedl syndrome 2	betaine--homocysteine S-methyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Microvillus Membrane Motile Cilium Stereocilium BBSome Ciliary Basal Body Neuron Projection Ciliary Membrane	Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding	Zinc Ion Binding Betaine-homocysteine S-methyltransferase Activity
	Biological Process	Sperm Axoneme Assembly Visual Perception Protein Localization Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Striatum Development Hippocampus Development Cerebral Cortex Development Adult Behavior Melanosome Transport Protein Localization To Organelle Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Vasodilation Golgi To Plasma Membrane Protein Transport Fat Cell Differentiation Photoreceptor Cell Maintenance Brain Morphogenesis Cartilage Development Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Non-motile Cilium Assembly	Sulfur Amino Acid Metabolic Process Protein Methylation Amino-acid Betaine Metabolic Process Amino-acid Betaine Catabolic Process Choline Catabolic Process S-adenosylmethionine Metabolic Process Regulation Of Homocysteine Metabolic Process L-methionine Salvage
Pathways		BBSome-mediated cargo-targeting to cilium	Sulfur amino acid metabolism Choline catabolism
Drugs			Methionine S-(D-Carboxybutyl)-L-Homocysteine
Diseases		Bardet-Biedl syndrome (BBS)
GWAS			Betaine levels in individuals undergoing cardiac evaluation ( 26822151) Blood and toenail selenium levels ( 25343990) Blood metabolite levels ( 24816252) Blood trace element (Se levels) ( 23720494) Metabolite levels ( 23823483 23378610) Toenail selenium levels ( 25343990)
Interacting Genes		15 interacting genes: BHMT EEF1A1 EPAS1 EXOC7 FHOD1 FNDC3B HNRNPF HSCB KRT18 LMO4 MDFI NRF1 PAX2 PSME3 RBPMS	6 interacting genes: ALG9 BBS1 BBS2 BBS4 LAMTOR3 LAMTOR5
Entrez ID		583	635
HPRD ID		05855	04200
Ensembl ID		ENSG00000125124	ENSG00000145692
Uniprot IDs		Q9BXC9	Q93088 V9HWA4
PDB IDs			1LT7 1LT8 4M3P
Enriched GO Terms of Interacting Partners?
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