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PTPN12 and KDR
Data Source:
BioGRID
(two hybrid)
PTPN12
KDR
Description
protein tyrosine phosphatase non-receptor type 12
kinase insert domain receptor
Image
GO Annotations
Cellular Component
Podosome
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Focal Adhesion
Cell Projection
Extracellular Region
Nucleus
Endosome
Early Endosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Junction
Receptor Complex
Membrane Raft
Sorting Endosome
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
Protein Binding
SH3 Domain Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Vascular Endothelial Growth Factor-activated Receptor Activity
Integrin Binding
Protein Binding
ATP Binding
Growth Factor Binding
Vascular Endothelial Growth Factor Binding
Identical Protein Binding
Cadherin Binding
Hsp90 Protein Binding
Biological Process
Protein Dephosphorylation
Peptidyl-tyrosine Dephosphorylation
ERBB2 Signaling Pathway
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Tissue Regeneration
Cellular Response To Cytokine Stimulus
Cellular Response To Epidermal Growth Factor Stimulus
Negative Regulation Of ERBB Signaling Pathway
Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Angiogenesis
Branching Involved In Blood Vessel Morphogenesis
Vasculogenesis
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Cell Migration Involved In Sprouting Angiogenesis
Hematopoietic Progenitor Cell Differentiation
Endothelium Development
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Gene Expression
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Positive Regulation Of Macroautophagy
Cell Migration
Peptidyl-tyrosine Phosphorylation
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Kinase Activity
Embryonic Hemopoiesis
Calcium-mediated Signaling Using Intracellular Calcium Source
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway
Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway
Peptidyl-tyrosine Autophosphorylation
Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Protein Kinase B Signaling
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Endothelial Cell Differentiation
Positive Regulation Of Angiogenesis
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Positive Chemotaxis
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Mitochondrial Depolarization
Vascular Wound Healing
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Mitochondrial Fission
Cellular Response To Hydrogen Sulfide
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Vasculogenesis
Pathways
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
EGFR downregulation
Signaling by PDGF
Downregulation of ERBB2 signaling
Interleukin-37 signaling
Constitutive Signaling by Overexpressed ERBB2
Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
Drugs
Tiludronic acid
Sorafenib
Sunitinib
1-{4-[4-Amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl}-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
Cediranib
Vatalanib
XL999
TG-100801
XL820
CYC116
Ramucirumab
Pegdinetanib
RAF-265
ABT-869
IMC-1C11
Semaxanib
Pazopanib
Midostaurin
Axitinib
4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide
N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide
N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide
6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide
N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE
N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE
3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one
3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one
N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide
N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
Cabozantinib
Regorafenib
Ponatinib
Lenvatinib
Nintedanib
Fostamatinib
Erdafitinib
Foretinib
Ripretinib
Pralsetinib
Diseases
GWAS
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Estimated glomerular filtration rate (
31015462
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Blood protein levels (
30072576
29875488
28240269
)
Endometriosis (
28537267
)
FEV1 (
30804560
)
Heel bone mineral density (
30598549
)
Lung function (FVC) (
30804560
)
Mosquito bite size (
28199695
)
Peak expiratory flow (
30804560
)
Serum VEGFR2 concentration (
25411163
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
57 interacting genes:
AATK
ABL1
ANP32B
APP
BAG6
BCAR1
CCDC180
CGA
CSH1
CSH2
CSK
EFS
EGFR
ERBB3
ERBB4
FANCC
FGFR2
FGFR4
FLT3
FRAT2
GRB2
IFT20
IGF1R
INSR
JAK2
KDR
LMTK2
LPXN
MYCBP2
NEDD9
PPP3R2
PRKACA
PRKCA
PSG9
PSTPIP1
PSTPIP2
PTK2
PTK2B
PTK7
PXN
RBM19
ROR2
SFRP4
SHC1
SMAD1
SMAD5
SORBS2
STX16
STX17
TENM1
TEX10
TGFB1I1
THAP2
UTRN
WAS
ZFP2
ZNF510
60 interacting genes:
ACP1
AIMP2
ANXA5
ATR
BMX
BTRC
CAV1
CBL
CCDC88A
CDH5
COL18A1
CRK
CSF2RB
CSNK1D
CTNNB1
DNM2
DUSP19
FBXO25
FBXW11
FLT1
FLT4
FRS2
FYN
GABARAP
GNA11
GNAQ
GRB10
GRB2
HSP90AA1
ILKAP
IQGAP1
ITGB3
MAPK1
NCK1
NRP1
P2RY2
PDCL3
PLCG1
PLCG2
PPM1A
PPM1B
PTPN11
PTPN12
PTPN6
PTPRR
RASA1
SERPINF1
SH2D2A
SHB
SHC1
SHC2
SRC
STAT1
STYX
SYNGAP1
TIMP3
VEGFA
VEGFC
VEGFD
YES1
Entrez ID
5782
3791
HPRD ID
02513
01867
Ensembl ID
ENSG00000127947
ENSG00000128052
Uniprot IDs
B4E105
Q05209
P35968
PDB IDs
5HDE
5J8R
5O2P
1VR2
1Y6A
1Y6B
1YWN
2M59
2MET
2MEU
2OH4
2P2H
2P2I
2QU5
2QU6
2RL5
2X1W
2X1X
2XIR
3B8Q
3B8R
3BE2
3C7Q
3CJF
3CJG
3CP9
3CPB
3CPC
3DTW
3EFL
3EWH
3KVQ
3S35
3S36
3S37
3U6J
3V2A
3V6B
3VHE
3VHK
3VID
3VNT
3VO3
3WZD
3WZE
4AG8
4AGC
4AGD
4ASD
4ASE
5EW3
5OYJ
6GQO
6GQP
6GQQ
6XVJ
6XVK
Enriched GO Terms of Interacting Partners
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