PTPN12 and PSTPIP2

Data Source:
BioGRID (affinity chromatography technology, proximity labelling technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		PTPN12	PSTPIP2
Description		protein tyrosine phosphatase non-receptor type 12	proline-serine-threonine phosphatase interacting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Cell Projection	Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding	Actin Filament Binding
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Tissue Regeneration Cellular Response To Cytokine Stimulus Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Cell Migration Actin Filament Polymerization
Pathways		SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2
Drugs		Tiludronic acid
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)	Iris color (b* coordinate) ( 30895295) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		57 interacting genes: AATK ABL1 ANP32B APP BAG6 BCAR1 CCDC180 CGA CSH1 CSH2 CSK EFS EGFR ERBB3 ERBB4 FANCC FGFR2 FGFR4 FLT3 FRAT2 GRB2 IFT20 IGF1R INSR JAK2 KDR LMTK2 LPXN MYCBP2 NEDD9 PPP3R2 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PTK7 PXN RBM19 ROR2 SFRP4 SHC1 SMAD1 SMAD5 SORBS2 STX16 STX17 TENM1 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2 ZNF510	4 interacting genes: KRT18 PTPN12 PTPN18 SHBG
Entrez ID		5782	9050
HPRD ID		02513	06687
Ensembl ID		ENSG00000127947	ENSG00000152229
Uniprot IDs		B4E105 Q05209	A0A0S2Z4R2 A0A0S2Z505 Q9H939
PDB IDs		5HDE 5J8R 5O2P
Enriched GO Terms of Interacting Partners?
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