PTPN12 and CCDC180

Data Source:
BioGRID (two hybrid)

		PTPN12	CCDC180
Description		protein tyrosine phosphatase non-receptor type 12	coiled-coil domain containing 180
Image			No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Cell Projection	Extracellular Exosome
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Tissue Regeneration Cellular Response To Cytokine Stimulus Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2
Drugs		Tiludronic acid
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)
Interacting Genes		57 interacting genes: AATK ABL1 ANP32B APP BAG6 BCAR1 CCDC180 CGA CSH1 CSH2 CSK EFS EGFR ERBB3 ERBB4 FANCC FGFR2 FGFR4 FLT3 FRAT2 GRB2 IFT20 IGF1R INSR JAK2 KDR LMTK2 LPXN MYCBP2 NEDD9 PPP3R2 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PTK7 PXN RBM19 ROR2 SFRP4 SHC1 SMAD1 SMAD5 SORBS2 STX16 STX17 TENM1 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2 ZNF510	20 interacting genes: BCL10 BUB1 CDKN2A CTNNA1 DLC1 ERBB2 FLCN MCC MLH1 MLH3 MSH2 NRAS PDGFRL PMS2 PTEN PTPN12 RB1 SMAD4 SRC STK11
Entrez ID		5782	100499483
HPRD ID		02513
Ensembl ID		ENSG00000127947	ENSG00000197816
Uniprot IDs		B4E105 Q05209	B4DZK1 Q9P1Z9
PDB IDs		5HDE 5J8R 5O2P
Enriched GO Terms of Interacting Partners?
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