SLC40A1 and GOLM1

Data Source:
HPRD (two hybrid)

		SLC40A1	GOLM1
Description		solute carrier family 40 member 1	golgi membrane protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane	Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Integral Component Of Plasma Membrane
	Molecular Function	Iron Ion Transmembrane Transporter Activity Protein Binding Ferrous Iron Transmembrane Transporter Activity Peptide Hormone Binding	Protein Binding
	Biological Process	Cellular Iron Ion Homeostasis Iron Ion Transmembrane Transport Iron Ion Homeostasis Multicellular Organismal Iron Ion Homeostasis Inorganic Cation Transmembrane Transport Iron Ion Export Across Plasma Membrane	Nucleus Organization Regulation Of Lipid Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Metal ion SLC transporters Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Defective CP causes aceruloplasminemia (ACERULOP) Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) Iron uptake and transport	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases		Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Bone fracture in osteoporosis ( 28580392) Hematocrit ( 32888494) Iron status biomarkers (ferritin levels) ( 25352340) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin levels) ( 25352340) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 27863252) Red blood cell count ( 27863252) Red cell distribution width ( 32888494)	Blood protein levels ( 30072576) Logical memory (delayed recall) in normal cognition ( 29274321)
Interacting Genes		3 interacting genes: GOLM1 HAMP SLC22A2	76 interacting genes: ABI3 AIG1 ANKRD46 ASPH B3GNT4 BCL2L1 C1orf174 C1QL4 CDIPT CIAO1 CLDN4 CLDND2 CLK1 CNPY3 DCK DCTN2 DESI1 DEXI EFTUD2 EIF2B3 EIF3J ELAC2 FLOT1 FTH1 FUT9 GALNT15 GAST GEMIN7 GET3 GLB1 GRIK5 GUCA2A HGFAC HSD17B13 IGFBP5 INSIG2 JAGN1 KCNE3 LAT LSM12 MED22 MIP NDUFV2 NEU1 NINJ1 NIPSNAP3A NRSN2 PGRMC1 RACK1 RIPPLY2 RPA2 RPL13A SFTPC SLC13A5 SLC30A3 SLC35B2 SLC40A1 SLC5A4 SLCO3A1 ST6GAL2 STRIT1 SYT1 TF THSD7A TMEM109 TMEM140 TMEM147 TMEM176A TMEM86B TMEM98 TMPO TMUB1 TMUB2 TSG101 VSTM1 ZFAND3
Entrez ID		30061	51280
HPRD ID		05229	08428
Ensembl ID		ENSG00000138449	ENSG00000135052
Uniprot IDs		Q9NP59	B3KNK9 Q8NBJ4
PDB IDs		6W4S 6WBV
Enriched GO Terms of Interacting Partners?
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