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TRIB3 and TRIM63
Data Source:
BioGRID
(two hybrid)
TRIB3
TRIM63
Description
tribbles pseudokinase 3
tripartite motif containing 63
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Nucleus
Cytoplasm
Microtubule
Z Disc
M Band
Molecular Function
Transcription Corepressor Activity
Protein Kinase Inhibitor Activity
Protein Binding
ATP Binding
Kinase Activity
Protein Kinase Binding
Mitogen-activated Protein Kinase Kinase Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-protein Transferase Regulator Activity
Protein Binding
Zinc Ion Binding
Titin Binding
Ubiquitin Protein Ligase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Regulation Of Autophagy
Regulation Of Glucose Transmembrane Transport
Regulation Of Lipid Metabolic Process
Positive Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Insulin Stimulus
Response To Endoplasmic Reticulum Stress
Regulation Of MAP Kinase Activity
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Fatty Acid Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Protein Kinase B Signaling
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Muscle Contraction
Signal Transduction
Negative Regulation Of Cardiac Muscle Hypertrophy
Skeletal Muscle Atrophy
Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation
Protein Ubiquitination
Response To Glucocorticoid
Response To Interleukin-1
Pathways
PIP3 activates AKT signaling
Activation of AKT2
PPARA activates gene expression
Negative regulation of the PI3K/AKT network
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
Response of EIF2AK4 (GCN2) to amino acid deficiency
Response of EIF2AK1 (HRI) to heme deficiency
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Information processing speed (
21130836
)
Logical memory (delayed recall) (
29274321
)
Logical memory (immediate recall) (
29274321
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Interacting Genes
99 interacting genes:
AKAP8L
AKT1
AKT2
APOBEC3A
APOBEC3C
APP
ARMC7
ATF4
BAG3
BCL6
BFSP2
BMPR2
C21orf58
C22orf39
CBX8
CHAF1A
CLCNKA
COPS6
CTAG1A
CTAG1B
DDIT3
DPPA3
DTX2
EEF1G
EFEMP2
EPHB6
EXOSC5
FAAP20
FAM161A
FAM90A1
FBXO7
GDF9
GIT1
GLIS3
GPATCH2L
GRB2
HAT1
HDAC4
HLA-B
HNRNPF
HOXB5
HOXC8
IL16
INCA1
INO80B
IRX6
KANK2
KAT5
KLHL38
KRT26
LENG1
LMO2
LMO3
MDFI
MISP
OIP5
OSTF1
PADI4
PARD6B
PCSK5
PITX2
PKNOX2
PML
PPP1R26
PPP1R32
PRKAB2
PRMT5
PRR19
PSMA3
RARA
RBM4
RBM48
RELA
RIDA
RPGRIP1
RPSA
SAMD11
SAXO1
SCNM1
SETDB1
SHFL
SNRPC
SPAG8
SPG21
SQSTM1
SUOX
TCF19
TEKT3
TEKT4
TLE5
TRIM55
TRIM63
TTC23
TWIST1
UBTD2
USP20
UTP23
ZNF417
ZNF587
329 interacting genes:
ACBD4
ACD
ACTA1
ADAMTSL4
AEBP2
AGO2
AK1
AKR7A2
ALDOA
ALKBH3
ANKRD1
ANKRD39
APLN
APOBEC4
APP
ARL6IP4
ATP5F1B
ATP5F1D
ATXN3
ATXN3L
ATXN7L1
BAP1
BCAT1
BCHE
BRD4
BRWD1
BTBD9
C10orf88
C12orf4
C1orf35
C3orf36
C8orf74
CADPS
CAMK2A
CAPN3
CARS1
CBX2
CCDC120
CCDC130
CCDC28B
CDK3
CDS2
CENPK
CHMP7
CKB
CKM
COA7
COX4I1
CRCT1
CTAG1A
CTAG1B
CTNNB1
CYB5R2
CYP46A1
CYTOR
DAPL1
DCAF11
DCAF6
DECR2
DEF8
DEK
DES
DNTTIP1
DOCK7
DYNLT2B
EED
EEF1G
EHHADH
EIF3E
ELAPOR1
ENO3
EPS8L2
ESPL1
EZH2
FAM185A
FANK1
FASTKD1
FHL2
FKBP6
FLNC
FRMD6
FYN
GABPB1
GATA3
GFM1
GLI4
GMEB1
GOLGA2P5
GPRIN2
GPS1
GRB10
HIBADH
HID1
HIRA
HOXA1
HROB
HSPB1
HSPD1
ID1
IFI35
IGF2
IK
IL37
ILF3
INCA1
ING4
INKA1
IQUB
IRF2
IRF3
ITGB5
JADE3
JOSD1
KBTBD4
KCTD15
KIAA0087
KIAA0408
KIAA0825
KIF5A
KLHDC4
KLHL36
KMT2B
KYAT1
LAMA2
LAMTOR5
LAPTM4A
LIMS2
LINC00518
LINC00663
LINC00905
LINC01588
LMCD1
LMO2
LRRC56
LYN
LYNX1
MAGEC3
MALSU1
MAP3K14
MBD4
MBIP
MCM7
MIDN
MIIP
MKI67
MLH3
MPP1
MPZL1
MRPL19
MRPL20-AS1
MRPL41
MSRB3
MYBPC1
MYBPC2
MYBPC3
MYBPHL
MYC
MYCT1
MYH6
MYL2
MYOT
MYOZ1
NDUFA1
NDUFA8
NEB
NEBL
NEFL
NGEF
NOMO1
NR1D2
NRAP
NSD3
NSUN7
NUFIP2
ODF2
OGFOD2
OTUB1
OTUB2
P3H3
PACRGL
PAFAH1B2
PCGF3
PCGF6
PDHB
PDK4
PELI3
PELO
PHC2
PHF23
PIAS1
PIAS2
PIAS3
PIP4K2B
PKM
PLEKHG4
PLXNA3
POLR2E
PPA2
PPARA
PPIE
PRKAB2
PRKACA
PRR30
PRRT1
PSMD4
PYGM
RAI2
RBM14
RELA
REX1BD
RGR
RHEB
RHPN1
RING1
RNASEH1
RNF10
RPS4X
RRAS
RUSC1
RUSC1-AS1
SEC23B
SENP2
SENP3
SET
SGCB
SHFL
SLC6A13
SLFN12
SNAPIN
SNW1
SPATS1
SPRYD7
SPSB1
SPSB2
SQSTM1
SRF
STAM
SUMO2
SYMPK
SYNCRIP
TCAP
TCEAL4
TCP10L
TEX19
THAP3
THRA
TIGD5
TIMM17B
TMBIM1
TMEM35A
TNIP3
TNNC1
TNNI1
TNNI2
TNNI3
TNNT1
TNNT3
TOR1AIP2
TPD52L3
TRAF3IP2
TRIB3
TRIM23
TRIM35
TRIM41
TRIM54
TRIM55
TRIM69
TRMT10B
TSC2
TSC22D4
TTN
TUBGCP4
UBA3
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2I
UBE2J1
UBE2K
UBE2N
UBE2U
UBE2V2
UCHL1
UCHL3
UCHL5
UNKL
UQCRC1
USP13
USP15
USP2
USP21
USP28
USP33
USP4
USP5
USP7
USP8
UXT
VAC14
VPS37A
WT1
XAGE1B
YOD1
YPEL3
ZBTB17
ZC2HC1C
ZC3H12A
ZC3HC1
ZFYVE19
ZNF124
ZNF20
ZNF302
ZNF333
ZNF345
ZNF431
ZNF436
ZNF460
ZNF566
ZNF57
ZNF581
ZNF597
ZNF649
ZNF653
ZNF667-AS1
ZNF767P
ZNF775
ZNF83
ZSCAN16
Entrez ID
57761
84676
HPRD ID
09836
05843
Ensembl ID
ENSG00000101255
ENSG00000158022
Uniprot IDs
B4DMM9
J3KR25
Q96RU7
Q969Q1
PDB IDs
2D8U
3DDT
4M3L
Enriched GO Terms of Interacting Partners
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