TRIB3 and BFSP2

Data Source:
BioGRID (two hybrid)

		TRIB3	BFSP2
Description		tribbles pseudokinase 3	beaded filament structural protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane	Intermediate Filament Plasma Membrane Cell Cortex
	Molecular Function	Transcription Corepressor Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity	Structural Constituent Of Cytoskeleton Structural Constituent Of Eye Lens Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Regulation Of Autophagy Regulation Of Glucose Transmembrane Transport Regulation Of Lipid Metabolic Process Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Regulation Of MAP Kinase Activity Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Kinase B Signaling Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress	Visual Perception Intermediate Filament Organization Cell Maturation Response To Stimulus Lens Fiber Cell Development
Pathways		PIP3 activates AKT signaling Activation of AKT2 PPARA activates gene expression Negative regulation of the PI3K/AKT network CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
GWAS		Information processing speed ( 21130836) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321)
Interacting Genes		99 interacting genes: AKAP8L AKT1 AKT2 APOBEC3A APOBEC3C APP ARMC7 ATF4 BAG3 BCL6 BFSP2 BMPR2 C21orf58 C22orf39 CBX8 CHAF1A CLCNKA COPS6 CTAG1A CTAG1B DDIT3 DPPA3 DTX2 EEF1G EFEMP2 EPHB6 EXOSC5 FAAP20 FAM161A FAM90A1 FBXO7 GDF9 GIT1 GLIS3 GPATCH2L GRB2 HAT1 HDAC4 HLA-B HNRNPF HOXB5 HOXC8 IL16 INCA1 INO80B IRX6 KANK2 KAT5 KLHL38 KRT26 LENG1 LMO2 LMO3 MDFI MISP OIP5 OSTF1 PADI4 PARD6B PCSK5 PITX2 PKNOX2 PML PPP1R26 PPP1R32 PRKAB2 PRMT5 PRR19 PSMA3 RARA RBM4 RBM48 RELA RIDA RPGRIP1 RPSA SAMD11 SAXO1 SCNM1 SETDB1 SHFL SNRPC SPAG8 SPG21 SQSTM1 SUOX TCF19 TEKT3 TEKT4 TLE5 TRIM55 TRIM63 TTC23 TWIST1 UBTD2 USP20 UTP23 ZNF417 ZNF587	56 interacting genes: ABI3 AMOTL2 ANKRD33 ATF4 BEX3 BEX5 BFSP1 BICRAL BLOC1S2 C3orf62 CAGE1 CALCOCO1 CCDC153 CCDC183 CDCA4 CDR2L CEP44 CEP63 COPS6 CT55 DISC1 DMAP1 ECSIT HAUS1 HGS KRT14 KRT24 KRT27 KRT31 KRT37 MAGEA6 MBIP MCCD1 MYOG OIP5 PBX2 PBX4 POU6F2 PPP1R13B PSMC5 RINT1 RNASE10 SAPCD2 SCOC SERTAD3 SNAPC5 SNAPIN SUFU SYCE1 SYCE1L TRIB3 USHBP1 USP54 WASHC3 ZNF343 ZNF620
Entrez ID		57761	8419
HPRD ID		09836	04444
Ensembl ID		ENSG00000101255	ENSG00000170819
Uniprot IDs		B4DMM9 J3KR25 Q96RU7	Q13515
PDB IDs
Enriched GO Terms of Interacting Partners?
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