TRIB3 and KRT26

Data Source:
BioGRID (two hybrid)

		TRIB3	KRT26
Description		tribbles pseudokinase 3	keratin 26
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane	Cytosol Intermediate Filament Extracellular Exosome
	Molecular Function	Transcription Corepressor Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity	Structural Molecule Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Regulation Of Autophagy Regulation Of Glucose Transmembrane Transport Regulation Of Lipid Metabolic Process Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Regulation Of MAP Kinase Activity Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Kinase B Signaling Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress	Keratinization Cornification
Pathways		PIP3 activates AKT signaling Activation of AKT2 PPARA activates gene expression Negative regulation of the PI3K/AKT network CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Information processing speed ( 21130836) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321)	Asthma ( 31959851) Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		99 interacting genes: AKAP8L AKT1 AKT2 APOBEC3A APOBEC3C APP ARMC7 ATF4 BAG3 BCL6 BFSP2 BMPR2 C21orf58 C22orf39 CBX8 CHAF1A CLCNKA COPS6 CTAG1A CTAG1B DDIT3 DPPA3 DTX2 EEF1G EFEMP2 EPHB6 EXOSC5 FAAP20 FAM161A FAM90A1 FBXO7 GDF9 GIT1 GLIS3 GPATCH2L GRB2 HAT1 HDAC4 HLA-B HNRNPF HOXB5 HOXC8 IL16 INCA1 INO80B IRX6 KANK2 KAT5 KLHL38 KRT26 LENG1 LMO2 LMO3 MDFI MISP OIP5 OSTF1 PADI4 PARD6B PCSK5 PITX2 PKNOX2 PML PPP1R26 PPP1R32 PRKAB2 PRMT5 PRR19 PSMA3 RARA RBM4 RBM48 RELA RIDA RPGRIP1 RPSA SAMD11 SAXO1 SCNM1 SETDB1 SHFL SNRPC SPAG8 SPG21 SQSTM1 SUOX TCF19 TEKT3 TEKT4 TLE5 TRIM55 TRIM63 TTC23 TWIST1 UBTD2 USP20 UTP23 ZNF417 ZNF587	23 interacting genes: BLOC1S2 CCDC146 FAM86C1P HGS KIFC3 KRT1 KRT3 KRT6A KRT6C KRT71 KRT74 KRT75 KRT81 KRT85 MCCD1 SLC19A1 SNAPIN SUOX TRIB3 TXLNB UCHL5 USHBP1 WASHC1
Entrez ID		57761	353288
HPRD ID		09836	17243
Ensembl ID		ENSG00000101255	ENSG00000186393
Uniprot IDs		B4DMM9 J3KR25 Q96RU7	Q7Z3Y9
PDB IDs
Enriched GO Terms of Interacting Partners?
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