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TRIM63 and IGF2
Data Source:
BioGRID
(two hybrid)
TRIM63
IGF2
Description
tripartite motif containing 63
insulin like growth factor 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Microtubule
Z Disc
M Band
Extracellular Region
Extracellular Space
Platelet Alpha Granule Lumen
Molecular Function
Protein Binding
Zinc Ion Binding
Titin Binding
Ubiquitin Protein Ligase Activity
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Integrin Binding
Hormone Activity
Protein Binding
Growth Factor Activity
Protein Serine/threonine Kinase Activator Activity
Receptor Ligand Activity
Biological Process
Muscle Contraction
Signal Transduction
Negative Regulation Of Cardiac Muscle Hypertrophy
Skeletal Muscle Atrophy
Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation
Protein Ubiquitination
Response To Glucocorticoid
Response To Interleukin-1
Negative Regulation Of Transcription By RNA Polymerase II
Skeletal System Development
Osteoblast Differentiation
In Utero Embryonic Development
Embryonic Placenta Development
Positive Regulation Of Protein Phosphorylation
Platelet Degranulation
Glucose Metabolic Process
Regulation Of Gene Expression By Genetic Imprinting
Regulation Of Transcription, DNA-templated
Multicellular Organism Development
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Animal Organ Morphogenesis
Exocrine Pancreas Development
Regulation Of Histone Modification
Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase
Positive Regulation Of Multicellular Organism Growth
Positive Regulation Of Activated T Cell Proliferation
Positive Regulation Of Catalytic Activity
Positive Regulation Of MAPK Cascade
Cellular Protein Metabolic Process
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Organ Growth
Positive Regulation Of Insulin Receptor Signaling Pathway
Positive Regulation Of Skeletal Muscle Tissue Growth
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Striated Muscle Cell Differentiation
Regulation Of Muscle Cell Differentiation
Negative Regulation Of Muscle Cell Differentiation
Positive Regulation Of Cell Division
Positive Regulation Of Protein Kinase B Signaling
Embryonic Placenta Morphogenesis
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Glycogen (starch) Synthase Activity
Pathways
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Antigen processing: Ubiquitination & Proteasome degradation
Platelet degranulation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
Beckwith-Wiedemann syndrome
Russell-Silver syndrome; Silver-Russell syndrome
Adrenal carcinoma
GWAS
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Birth weight (
27680694
)
Celiac disease (
23936387
)
Creatinine levels (
29403010
)
DNA methylation (variation) (
23725790
)
Estimated glomerular filtration rate (
31015462
30604766
)
Femoral neck bone geometry and menarche (age at onset) (
23593202
)
Glomerular filtration rate (
29403010
)
Length of menstrual cycle (
30202859
)
Periventricular white matter hyperintensities (
32517579
)
Prostate cancer (
19767753
)
Pursuit maintenance gain (
29064472
)
Type 2 diabetes (
30297969
32499647
30718926
)
Urate levels (
31578528
)
Interacting Genes
329 interacting genes:
ACBD4
ACD
ACTA1
ADAMTSL4
AEBP2
AGO2
AK1
AKR7A2
ALDOA
ALKBH3
ANKRD1
ANKRD39
APLN
APOBEC4
APP
ARL6IP4
ATP5F1B
ATP5F1D
ATXN3
ATXN3L
ATXN7L1
BAP1
BCAT1
BCHE
BRD4
BRWD1
BTBD9
C10orf88
C12orf4
C1orf35
C3orf36
C8orf74
CADPS
CAMK2A
CAPN3
CARS1
CBX2
CCDC120
CCDC130
CCDC28B
CDK3
CDS2
CENPK
CHMP7
CKB
CKM
COA7
COX4I1
CRCT1
CTAG1A
CTAG1B
CTNNB1
CYB5R2
CYP46A1
CYTOR
DAPL1
DCAF11
DCAF6
DECR2
DEF8
DEK
DES
DNTTIP1
DOCK7
DYNLT2B
EED
EEF1G
EHHADH
EIF3E
ELAPOR1
ENO3
EPS8L2
ESPL1
EZH2
FAM185A
FANK1
FASTKD1
FHL2
FKBP6
FLNC
FRMD6
FYN
GABPB1
GATA3
GFM1
GLI4
GMEB1
GOLGA2P5
GPRIN2
GPS1
GRB10
HIBADH
HID1
HIRA
HOXA1
HROB
HSPB1
HSPD1
ID1
IFI35
IGF2
IK
IL37
ILF3
INCA1
ING4
INKA1
IQUB
IRF2
IRF3
ITGB5
JADE3
JOSD1
KBTBD4
KCTD15
KIAA0087
KIAA0408
KIAA0825
KIF5A
KLHDC4
KLHL36
KMT2B
KYAT1
LAMA2
LAMTOR5
LAPTM4A
LIMS2
LINC00518
LINC00663
LINC00905
LINC01588
LMCD1
LMO2
LRRC56
LYN
LYNX1
MAGEC3
MALSU1
MAP3K14
MBD4
MBIP
MCM7
MIDN
MIIP
MKI67
MLH3
MPP1
MPZL1
MRPL19
MRPL20-AS1
MRPL41
MSRB3
MYBPC1
MYBPC2
MYBPC3
MYBPHL
MYC
MYCT1
MYH6
MYL2
MYOT
MYOZ1
NDUFA1
NDUFA8
NEB
NEBL
NEFL
NGEF
NOMO1
NR1D2
NRAP
NSD3
NSUN7
NUFIP2
ODF2
OGFOD2
OTUB1
OTUB2
P3H3
PACRGL
PAFAH1B2
PCGF3
PCGF6
PDHB
PDK4
PELI3
PELO
PHC2
PHF23
PIAS1
PIAS2
PIAS3
PIP4K2B
PKM
PLEKHG4
PLXNA3
POLR2E
PPA2
PPARA
PPIE
PRKAB2
PRKACA
PRR30
PRRT1
PSMD4
PYGM
RAI2
RBM14
RELA
REX1BD
RGR
RHEB
RHPN1
RING1
RNASEH1
RNF10
RPS4X
RRAS
RUSC1
RUSC1-AS1
SEC23B
SENP2
SENP3
SET
SGCB
SHFL
SLC6A13
SLFN12
SNAPIN
SNW1
SPATS1
SPRYD7
SPSB1
SPSB2
SQSTM1
SRF
STAM
SUMO2
SYMPK
SYNCRIP
TCAP
TCEAL4
TCP10L
TEX19
THAP3
THRA
TIGD5
TIMM17B
TMBIM1
TMEM35A
TNIP3
TNNC1
TNNI1
TNNI2
TNNI3
TNNT1
TNNT3
TOR1AIP2
TPD52L3
TRAF3IP2
TRIB3
TRIM23
TRIM35
TRIM41
TRIM54
TRIM55
TRIM69
TRMT10B
TSC2
TSC22D4
TTN
TUBGCP4
UBA3
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2I
UBE2J1
UBE2K
UBE2N
UBE2U
UBE2V2
UCHL1
UCHL3
UCHL5
UNKL
UQCRC1
USP13
USP15
USP2
USP21
USP28
USP33
USP4
USP5
USP7
USP8
UXT
VAC14
VPS37A
WT1
XAGE1B
YOD1
YPEL3
ZBTB17
ZC2HC1C
ZC3H12A
ZC3HC1
ZFYVE19
ZNF124
ZNF20
ZNF302
ZNF333
ZNF345
ZNF431
ZNF436
ZNF460
ZNF566
ZNF57
ZNF581
ZNF597
ZNF649
ZNF653
ZNF667-AS1
ZNF767P
ZNF775
ZNF83
ZSCAN16
26 interacting genes:
BAG6
CCN3
CCN5
CLN5
FAF1
GPC3
GPR152
IDE
IGF1R
IGF2R
IGFBP1
IGFBP2
IGFBP3
IGFBP4
IGFBP5
IGFBP6
IGFBP7
INSR
NMRK2
PCSK4
PLG
RBPMS
TF
TRIM55
TRIM63
VTN
Entrez ID
84676
3481
HPRD ID
05843
00939
Ensembl ID
ENSG00000158022
ENSG00000167244
Uniprot IDs
Q969Q1
E3UN46
P01344
PDB IDs
2D8U
3DDT
4M3L
1GF2
1IGL
2L29
2V5P
3E4Z
3KR3
5L3L
5L3M
5L3N
6UM2
6VWG
6VWI
Enriched GO Terms of Interacting Partners
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