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CRK and CBL
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro, in vivo)
CRK
CBL
Description
CRK proto-oncogene, adaptor protein
Cbl proto-oncogene
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Actin Cytoskeleton
Membrane
Protein-containing Complex
Membrane Raft
Extracellular Exosome
Golgi Apparatus
Cytosol
Plasma Membrane
Focal Adhesion
Cilium
Flotillin Complex
Growth Cone
Membrane Raft
Perinuclear Region Of Cytoplasm
Molecular Function
Phosphotyrosine Residue Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Cytoskeletal Protein Binding
SH3 Domain Binding
Kinase Binding
Signaling Receptor Complex Adaptor Activity
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
SH2 Domain Binding
Protein Self-association
Protein Phosphorylated Amino Acid Binding
Ephrin Receptor Binding
Scaffold Protein Binding
Protein Tyrosine Kinase Binding
Phosphotyrosine Residue Binding
Ubiquitin-protein Transferase Activity
Epidermal Growth Factor Receptor Binding
Calcium Ion Binding
Protein Binding
SH3 Domain Binding
Receptor Tyrosine Kinase Binding
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
Cadherin Binding
Ephrin Receptor Binding
Ubiquitin Protein Ligase Activity
Biological Process
Activation Of MAPKK Activity
Neuron Migration
Response To Yeast
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Regulation Of Cell Shape
Regulation Of Signal Transduction
Positive Regulation Of Smooth Muscle Cell Migration
Dendrite Development
Cytokine-mediated Signaling Pathway
Hippocampus Development
Cerebral Cortex Development
Establishment Of Cell Polarity
Actin Cytoskeleton Organization
Regulation Of Actin Cytoskeleton Organization
Regulation Of Cell Adhesion Mediated By Integrin
Regulation Of Rac Protein Signal Transduction
Helper T Cell Diapedesis
Response To Hepatocyte Growth Factor
Reelin-mediated Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Response To Hydrogen Peroxide
Regulation Of GTPase Activity
Regulation Of Protein Binding
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Regulation Of Dendrite Development
Cell Chemotaxis
Negative Regulation Of Wound Healing
Response To Cholecystokinin
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To Nitric Oxide
Activation Of GTPase Activity
Cerebellar Neuron Development
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Regulation Of Intracellular Signal Transduction
Cellular Response To Nerve Growth Factor Stimulus
Cellular Response To Insulin-like Growth Factor Stimulus
Cellular Response To Endothelin
Negative Regulation Of Cell Motility
Regulation Of T Cell Migration
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Cellular Response To DNA Damage Stimulus
Signal Transduction
Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity
Transforming Growth Factor Beta Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Male Gonad Development
Response To Gamma Radiation
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Response To Activity
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Regulation Of Rap Protein Signal Transduction
Response To Testosterone
Entry Of Bacterium Into Host Cell
Cellular Response To Platelet-derived Growth Factor Stimulus
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Response To Starvation
Negative Regulation Of Apoptotic Process
Mast Cell Degranulation
Response To Ethanol
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Response To Antibiotic
Positive Regulation Of Receptor-mediated Endocytosis
Membrane Organization
Interleukin-6-mediated Signaling Pathway
Neuron Death
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Oxygen-glucose Deprivation
Negative Regulation Of Neuron Death
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Pathways
ARMS-mediated activation
ARMS-mediated activation
Downstream signal transduction
Regulation of actin dynamics for phagocytic cup formation
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAP1 and RAC1
MET receptor recycling
Regulation of signaling by CBL
FCGR3A-mediated phagocytosis
Interleukin-6 signaling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Spry regulation of FGF signaling
Regulation of KIT signaling
EGFR downregulation
TGF-beta receptor signaling activates SMADs
Constitutive Signaling by EGFRvIII
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Negative regulation of MET activity
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
Regulation of signaling by CBL
Regulation of signaling by CBL
Negative regulation of FLT3
FLT3 signaling by CBL mutants
Drugs
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Atrial fibrillation (
30061737
)
Granulocyte count (
27863252
)
Intraocular pressure (
30591961
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Myeloid white cell count (
27863252
)
Neutrophil count (
27863252
)
Pulse pressure (
27841878
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Systolic blood pressure (
28135244
27841878
30578418
)
High light scatter reticulocyte count (
32888494
27863252
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Platelet count (
22139419
29403010
32888494
27863252
)
Plateletcrit (
32888494
27863252
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Interacting Genes
169 interacting genes:
ABL1
ABL2
ANKZF1
ANLN
AR
ARHGAP17
ARHGAP32
ASAP1
ASAP3
ASCL4
ATF3
ATXN1
AVIL
BATF3
BCAR1
BCR
BEX5
BUB1
C1orf94
C4orf17
C6orf141
CBL
CBLB
CBLC
CHTF18
CLNK
CNDP2
CORO6
CRKL
DAB1
DOCK1
DOCK3
DOK1
DOK2
DOK3
DOK4
DOK7
DPPA4
EFS
EGFR
ELK1
ELK3
EPHA3
EPHB2
EPHB3
EPHB6
EPS15
EPYC
ERBB2
ERBB3
ERBB4
ESD
EYA3
FASLG
FER
FGFR1
FLACC1
FLT1
FRS2
FSTL1
FYN
GAB1
GABPB2
GAREM1
GRB2
HABP4
HSH2D
IFT140
IGF1R
IKZF3
INO80E
INSR
IRS1
IRS2
IRS4
ISL1
KCTD13
KCTD17
KDR
KHDRBS1
KIT
KLF15
KLHL20
LASP1
LHX8
LNX2
MAGEC3
MAP4K1
MAP4K5
MAPK4
MAPK8
MET
MICAL1
MNDA
MPG
MYLIP
MYOZ2
NCK1
NEDD9
NTRK1
NUFIP2
OFCC1
PAFAH1B2
PDGFRA
PDGFRB
PHC2
PIK3R1
PIK3R2
PIK3R3
PLSCR1
POT1
PPFIBP2
PPP1CA
PRKACA
PRRC2B
PRRG2
PSMC1
PSMC6
PTK2
PTK2B
PTPN1
PTPN4
PTPRH
PTTG1
PXN
RAB2B
RAPGEF1
REPS1
RET
RIN3
RTCB
RYBP
SASH1
SAXO1
SEMA4D
SEPTIN6
SETD9
SH2D2A
SH3BP1
SHB
SHC1
SOCS1
SOCS6
SOS1
SPRR2A
STAT4
STAT5A
STAT5B
STRN4
SYN1
TCAP
TDG
TERF2IP
TM4SF19
TP53
TP53BP2
TUBA1C
TWIST2
TXK
USP53
VAC14
VAV1
WASF1
WDR83
WEE1
XPO1
ZAP70
ZKSCAN7
ZNF557
128 interacting genes:
ABL1
APPL1
ASAP1
AXL
BCR
BLK
BLNK
BTK
CAPN1
CBLIF
CD19
CD2AP
CD38
CD40
CD5
CDKL2
CRK
CRKL
CSF1R
CTNNB1
CUBN
EGFR
EIF5B
EPHA2
EPHB6
EPOR
EPS8
F2RL1
FGR
FLOT1
FLT3
FNBP1
FRS2
FYB1
FYN
GRAP2
GRB2
HCK
IGF1R
INPPL1
INSR
ITCH
ITK
ITSN2
JAK2
KDR
KHDRBS1
KIT
KRT18
LAT
LAT2
LCK
LCP2
LRIG1
LTK
LYN
MAPK8
MET
MYH9
MYO1C
MZF1
NCK1
NECTIN1
NOTCH1
OSTF1
PDGFRA
PDGFRB
PIK3R1
PIK3R2
PLCG1
PRKCA
PRKCQ
PTK2B
PTPN11
PTPN22
PTPN6
RET
SCN5A
SERPINA5
SH2B2
SH3KBP1
SHC1
SLA
SLA2
SMAD7
SORBS1
SORBS2
SP7
SPRY2
SRC
STAP2
STAT3
STAT5A
STAT5B
SYK
TCN1
TCN2
TGM2
TNFRSF11A
TNS4
TRAF4
TRAF6
TRIM8
TYK2
UBASH3B
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2L3
UBE2M
UBE2N
UBE2U
UBE2W
USP21
VAV1
VAV2
YES1
YWHAB
YWHAG
YWHAQ
YWHAZ
ZAP70
Entrez ID
1398
867
HPRD ID
01267
01320
Ensembl ID
ENSG00000167193
ENSG00000110395
Uniprot IDs
A0A0S2Z3K9
A0A0S2Z3Q4
L7RT18
P46108
P22681
PDB IDs
1JU5
2DVJ
2EYV
2EYW
2EYX
2EYY
2EYZ
2MS4
5UL6
6ATV
1B47
1FBV
1YVH
2CBL
2JUJ
2K4D
2OO9
2Y1M
2Y1N
3BUM
3BUN
3BUO
3BUW
3BUX
3OB1
3OB2
3PLF
4A49
4A4B
4A4C
4GPL
5HKW
5HKX
5HKY
5HKZ
5HL0
5J3X
5O76
6O02
6O03
Enriched GO Terms of Interacting Partners
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