CRK and EPHB2

Data Source:
BioGRID (pull down)

		CRK	EPHB2
Description		CRK proto-oncogene, adaptor protein	EPH receptor B2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Membrane Protein-containing Complex Membrane Raft Extracellular Exosome	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Neuron Projection Neuronal Cell Body Receptor Complex Postsynapse Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Phosphotyrosine Residue Binding Insulin-like Growth Factor Receptor Binding Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Kinase Binding Signaling Receptor Complex Adaptor Activity Ubiquitin Protein Ligase Binding Signaling Adaptor Activity SH2 Domain Binding Protein Self-association Protein Phosphorylated Amino Acid Binding Ephrin Receptor Binding Scaffold Protein Binding Protein Tyrosine Kinase Binding	Amyloid-beta Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Signaling Receptor Binding Protein Binding ATP Binding Axon Guidance Receptor Activity Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Activation Of MAPKK Activity Neuron Migration Response To Yeast Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Regulation Of Cell Shape Regulation Of Signal Transduction Positive Regulation Of Smooth Muscle Cell Migration Dendrite Development Cytokine-mediated Signaling Pathway Hippocampus Development Cerebral Cortex Development Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Rac Protein Signal Transduction Helper T Cell Diapedesis Response To Hepatocyte Growth Factor Reelin-mediated Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Hydrogen Peroxide Regulation Of GTPase Activity Regulation Of Protein Binding Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Dendrite Development Cell Chemotaxis Negative Regulation Of Wound Healing Response To Cholecystokinin Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Nitric Oxide Activation Of GTPase Activity Cerebellar Neuron Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Intracellular Signal Transduction Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Cellular Response To Endothelin Negative Regulation Of Cell Motility Regulation Of T Cell Migration	Angiogenesis Urogenital System Development Negative Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Axon Guidance Axonal Fasciculation Learning Or Memory Learning Positive Regulation Of Gene Expression Phosphorylation Peptidyl-tyrosine Phosphorylation Optic Nerve Morphogenesis Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Regulation Of Blood Coagulation Retinal Ganglion Cell Axon Guidance Positive Regulation Of Synaptic Plasticity Positive Regulation Of Kinase Activity Inner Ear Morphogenesis Negative Regulation Of Ras Protein Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Camera-type Eye Morphogenesis Negative Regulation Of Axonogenesis Regulation Of Body Fluid Levels Inactivation Of MAPKK Activity Positive Regulation Of Synapse Assembly Roof Of Mouth Development Dendritic Spine Development Dendritic Spine Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Commissural Neuron Axon Guidance Postsynaptic Membrane Assembly Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission Neuron Projection Retraction Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of NMDA Glutamate Receptor Activity Positive Regulation Of NMDA Glutamate Receptor Activity
Pathways		ARMS-mediated activation ARMS-mediated activation Downstream signal transduction Regulation of actin dynamics for phagocytic cup formation p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 MET receptor recycling Regulation of signaling by CBL FCGR3A-mediated phagocytosis	EPH-Ephrin signaling EPH-Ephrin signaling L1CAM interactions EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs			Phosphoaminophosphonic Acid-Adenylate Ester Fostamatinib
Diseases
GWAS		Atrial fibrillation ( 30061737) Granulocyte count ( 27863252) Intraocular pressure ( 30591961) Lymphocyte percentage of white cells ( 32888494 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Pulse pressure ( 27841878) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 28135244 27841878 30578418)	Blood protein levels ( 30072576 29875488 28240269) Refractive error ( 32231278) Triiodothyronine levels ( 30843173) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		169 interacting genes: ABL1 ABL2 ANKZF1 ANLN AR ARHGAP17 ARHGAP32 ASAP1 ASAP3 ASCL4 ATF3 ATXN1 AVIL BATF3 BCAR1 BCR BEX5 BUB1 C1orf94 C4orf17 C6orf141 CBL CBLB CBLC CHTF18 CLNK CNDP2 CORO6 CRKL DAB1 DOCK1 DOCK3 DOK1 DOK2 DOK3 DOK4 DOK7 DPPA4 EFS EGFR ELK1 ELK3 EPHA3 EPHB2 EPHB3 EPHB6 EPS15 EPYC ERBB2 ERBB3 ERBB4 ESD EYA3 FASLG FER FGFR1 FLACC1 FLT1 FRS2 FSTL1 FYN GAB1 GABPB2 GAREM1 GRB2 HABP4 HSH2D IFT140 IGF1R IKZF3 INO80E INSR IRS1 IRS2 IRS4 ISL1 KCTD13 KCTD17 KDR KHDRBS1 KIT KLF15 KLHL20 LASP1 LHX8 LNX2 MAGEC3 MAP4K1 MAP4K5 MAPK4 MAPK8 MET MICAL1 MNDA MPG MYLIP MYOZ2 NCK1 NEDD9 NTRK1 NUFIP2 OFCC1 PAFAH1B2 PDGFRA PDGFRB PHC2 PIK3R1 PIK3R2 PIK3R3 PLSCR1 POT1 PPFIBP2 PPP1CA PRKACA PRRC2B PRRG2 PSMC1 PSMC6 PTK2 PTK2B PTPN1 PTPN4 PTPRH PTTG1 PXN RAB2B RAPGEF1 REPS1 RET RIN3 RTCB RYBP SASH1 SAXO1 SEMA4D SEPTIN6 SETD9 SH2D2A SH3BP1 SHB SHC1 SOCS1 SOCS6 SOS1 SPRR2A STAT4 STAT5A STAT5B STRN4 SYN1 TCAP TDG TERF2IP TM4SF19 TP53 TP53BP2 TUBA1C TWIST2 TXK USP53 VAC14 VAV1 WASF1 WDR83 WEE1 XPO1 ZAP70 ZKSCAN7 ZNF557	39 interacting genes: ABL1 ABL2 ACP1 AFDN AQP1 ARHGEF6 CRK EFNA5 EFNB1 EFNB2 ERBB2 ERF FBXO7 FOS GRB2 GRIN1 GRIN2B ITSN1 KALRN KSR1 MMP2 MMP9 MTMR14 NCK1 PICK1 PLCG1 PTK2 RASA1 RRAS RYK SDC2 SDCBP SH2D3C SRC SYNJ1 TRIM54 VAV2 VEGFA YES1
Entrez ID		1398	2048
HPRD ID		01267	02997
Ensembl ID		ENSG00000167193	ENSG00000133216
Uniprot IDs		A0A0S2Z3K9 A0A0S2Z3Q4 L7RT18 P46108	B4DSE0 P29323 Q4LE53 Q6NVW1
PDB IDs		1JU5 2DVJ 2EYV 2EYW 2EYX 2EYY 2EYZ 2MS4 5UL6 6ATV	1B4F 1F0M 2QBX 3ZFM
Enriched GO Terms of Interacting Partners?
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