RANBP10 and IGFBP6

Data Source:
BioGRID (two hybrid)

		RANBP10	IGFBP6
Description		RAN binding protein 10	insulin like growth factor binding protein 6
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol	Extracellular Region Extracellular Space Golgi Apparatus Insulin-like Growth Factor Binary Complex
	Molecular Function	Protein Binding	Fibronectin Binding Signaling Receptor Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Identical Protein Binding
	Biological Process	Cytoskeleton Organization Cell Surface Receptor Signaling Pathway	Activation Of MAPK Activity Signal Transduction Negative Regulation Of Cell Population Proliferation Cell Migration Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		MET activates RAS signaling	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Empathy quotient ( 29527006) HDL cholesterol ( 25961943) Hematocrit ( 32888494 27863252) Hemoglobin concentration ( 27863252) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)
Interacting Genes		16 interacting genes: CACHD1 CNTNAP4 CTAG1A CTAG1B IGFBP6 IGSF1 MAEA MAGEA11 MEGF10 MET NEDD4 NEDD4L PRKCG RAN THSD7B TSEN2	37 interacting genes: ALPP ANKRD11 AQP1 C1orf74 CCDC116 CCDC28A CDIPT CREB5 EFEMP1 EFEMP2 ENKD1 EPDR1 GAS8 GET3 IGF1 IGF2 KRTAP10-8 KRTAP5-7 KRTAP5-9 MBD3 MEIS2 MSGN1 NCALD PLEKHA7 POU4F2 RABGGTB RANBP10 SDCBP SGTA SMCP TF UBAC1 UBQLN1 UBQLN2 UBQLN4 ZNF417 ZNF587
Entrez ID		57610	3489
HPRD ID		15207	00902
Ensembl ID		ENSG00000141084	ENSG00000167779
Uniprot IDs		B3KP49 Q6VN20 R4GMX8	P24592
PDB IDs			1RMJ
Enriched GO Terms of Interacting Partners?
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